SYNTHESIS AND ANTITUMOR-ACTIVITY OF NOVEL ALPHA-SUBSTITUTED AMINOMETHYLPHOSPHONATES

被引：20
|
作者：
CHEN, RY
MAO, LJ
机构：
[1] Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R.
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1994年 / 89卷 / 1-4期
基金：
中国国家自然科学基金;
关键词：
AMINOMETHYLPHOSPHONATE; SYNTHESIS; ANTITUMOR ACTIVITY; X-RAY DIFFRACTION;
D O I：
10.1080/10426509408020438
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two series of novel cu-substituted aminomethyl phosphonates (1) and (2) have been synthesized and the reaction conditions are discussed. All the products have been confirmed by H-1 NMR, IR spectra and elemental analysis, and x-ray diffraction. The bioassay showed that some of the compounds inhibit the growth of the leukemia L(1210) cell in vitro.
引用
收藏
页码：97 / 104
页数：8
相关论文
共 50 条
  • [31] SYNTHESIS AND ANTITUMOR-ACTIVITY OF QUINOCARCIN DERIVATIVES
    SAITO, H
    UOSAKI, Y
    SATO, A
    HIRATA, T
    MORIMOTO, M
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S171 - S171
  • [32] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL BENZOYLPHENYLUREA DERIVATIVES FOR ANTITUMOR-ACTIVITY
    OKADA, H
    AKAGI, T
    KOYANAGI, T
    YAMADA, N
    HAGA, T
    NAKAJIMA, T
    WATANABE, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 21 - MEDI
  • [33] 3'-HYDROXYESORUBICIN - SYNTHESIS AND ANTITUMOR-ACTIVITY
    PRIEBE, W
    NEAMATI, N
    PEREZSOLER, R
    JOURNAL OF ANTIBIOTICS, 1990, 43 (07): : 838 - 846
  • [34] SYNTHESIS AND ANTITUMOR-ACTIVITY OF DUOCARMYCIN DERIVATIVES
    NAGAMURA, S
    KANDA, Y
    KOBAYASHI, E
    GOMI, K
    SAITO, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (09) : 1530 - 1535
  • [35] SYNTHESIS AND ANTITUMOR-ACTIVITY OF CAMPTOTHECIN ANALOGS
    TERASAWA, H
    EJIMA, A
    SUGIMORI, M
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1991, 49 (11) : 1013 - 1020
  • [36] SYNTHESIS AND ANTITUMOR-ACTIVITY OF ISODOXORUBICIN ANALOGS
    FLORENT, JC
    GAUDEL, G
    MONNERET, C
    HOFFMANN, D
    KRAEMER, HP
    JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (10) : 1364 - 1368
  • [37] NOVEL ETHYNYLATION OF ALPHA-SUBSTITUTED MESITYL OXIDES
    FUJITA, Y
    WADA, F
    ONISHI, T
    NISHIDA, T
    CHEMISTRY LETTERS, 1977, (08) : 943 - 946
  • [38] POTENTIAL ANTITUMOR AGENTS .51. SYNTHESIS AND ANTITUMOR-ACTIVITY OF SUBSTITUTED PHENAZINE-1-CARBOXAMIDES
    REWCASTLE, GW
    DENNY, WA
    BAGULEY, BC
    JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (05) : 843 - 851
  • [39] CHEMICAL MODIFICATION OF AN ANTITUMOR ALKALOID CAMPTOTHECIN - SYNTHESIS AND ANTITUMOR-ACTIVITY OF 7-C-SUBSTITUTED CAMPTOTHECINS
    SAWADA, S
    NOKATA, KI
    FURUTA, T
    YOKOKURA, T
    MIYASAKA, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (10) : 2574 - 2580
  • [40] SYNTHESIS AND ANTITUMOR-ACTIVITY OF A NOVEL DIPLATINUM COMPLEX OF THE BINUCLEATING NAPHTHAZARINATO LIGAND
    PAPAGEORGIOU, VP
    CHRISTIANOPOULOU, MM
    BOUTIS, LL
    PAPAGEORGIOU, A
    TSIPIS, CA
    INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1986, 124 (04): : 203 - 206
12345