SYNTHESIS AND ANTITUMOR-ACTIVITY OF NOVEL ALPHA-SUBSTITUTED AMINOMETHYLPHOSPHONATES

被引：20
|
作者：
CHEN, RY
MAO, LJ
机构：
[1] Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R.
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1994年 / 89卷 / 1-4期
基金：
中国国家自然科学基金;
关键词：
AMINOMETHYLPHOSPHONATE; SYNTHESIS; ANTITUMOR ACTIVITY; X-RAY DIFFRACTION;
D O I：
10.1080/10426509408020438
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two series of novel cu-substituted aminomethyl phosphonates (1) and (2) have been synthesized and the reaction conditions are discussed. All the products have been confirmed by H-1 NMR, IR spectra and elemental analysis, and x-ray diffraction. The bioassay showed that some of the compounds inhibit the growth of the leukemia L(1210) cell in vitro.
引用
收藏
页码：97 / 104
页数：8
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