L-DOPA INHIBITS INVITRO PHOSPHORYLATION OF MELANOMA GLYCOPROTEINS

被引：18
|
作者：
SLOMINSKI, A
FRIEDRICH, T
机构：
[1] Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, Albany, New York
来源：
PIGMENT CELL RESEARCH | 1992年 / 5卷 / 06期
关键词：
L-DIHYDROXYPHENYLALANINE; PROTEIN PHOSPHORYLATION; MELANOGENESIS; MELANOCYTES;
D O I：
10.1111/j.1600-0749.1992.tb00569.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
L-DOPA had no effect on the endogenous phosphorylation of proteins after extraction with 1% Triton X-100 from hamster melanoma. When proteins were purified further by wheat germ-agglutinin chromatography, however, a dramatic and dose-dependent inhibtory effect of DOPA on glycoprotein phosphorylation was observed in the presence of Mn+2.
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页码：396 / 399
页数：4
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