(1'S,6'S,8'S,9'R)-9'-Bromo-12'-oxaspiro-[1,3-dioxolane-2,4'-tricyclo[6.3.1.0(1,6)]-dodecane]

被引：0
|
作者：
Mehta, Goverdhan [1 ,2 ]
Khan, Tabrez Babu [1 ,2 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
[2] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2012年 / 68卷
关键词：
data-to-parameter ratio = 15.4; mean σ(C-C) = 0.003 Å; R factor = 0.030; single-crystal X-ray study; T = 296 K; wR factor = 0.076;
D O I：
10.1107/S1600536812029777
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In an endeavor directed towards the construction of the oxabicyclic[3.2.1] octane segment present in the bioactive natural products of cortistatins and icetexanes genre, the title compound, C13H19BrO3, was synthesized from (4aR,9aS)-1,3,4,4a,5,6,9,9a-octahydrospiro[benzo[7] annulene-2,20-[1,3]dioxolane]-4a-ol via a transannular bromo-etherification protocol. The six-membered ring adopts a twist-boat conformation, while the fused cycloheptane ring adopts a chair conformation. The crystal packing is effected through two distinct intermolecular C-H center dot center dot center dot O hydrogen-bond patterns and molecules are arranged to define an interesting motif along the b axis.
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页码：02411 / +
页数：9
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