HUMAN MITOCHONDRIAL ATP SYNTHASE - CLONING CDNA FOR THE NUCLEAR-ENCODED PRECURSOR OF COUPLING FACTOR-6

被引：6

作者：

JAVED, AA ^{[1
]}

OGATA, K ^{[1
]}

SANADI, DR ^{[1
]}

机构：

[1] BOSTON BIOMED RES INST,DEPT CELL BIOL,BOSTON,MA 02114

来源：

GENE | 1991年 / 97卷 / 02期

关键词：

RECOMBINANT DNA; H+-TRANSLOCATING ATPASE; PHAGE-LAMBDA LIBRARY; SEQUENCING;

D O I：

10.1016/0378-1119(91)90068-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments. A human fetal muscle cDNA clone encoding this protein was isolated by screening a lambda-gt10 library with oligodeoxyribonucleotide probes. The 497-bp F6 cDNA included a 96-bp segment that delineated a presequence of 32 amino acids (aa) in the precursor protein, and 140 bp of 3'-untranslated sequence. The remainder of the cDNA sequence coded for a mature human F6 protein of 76 aa. The deduced primary aa sequence showed 81% homology to that of bovine F6, differing in 14 aa. Almost all of these aa substitutions were conservative and comparison of the hydropathy profiles revealed a similar pattern.

引用

页码：307 / 310

页数：4

共 50 条

[21] THE NUCLEAR-ENCODED POLYPEPTIDE CFO-II FROM SPINACH IS A REAL, 9TH SUBUNIT OF CHLOROPLAST ATP SYNTHASE
HERRMANN, RG
STEPPUHN, J
HERRMANN, GS
NELSON, N
FEBS LETTERS, 1993, 326 (1-3) : 192 - 198
[22] Nuclear-encoded sigma factor 6 (SIG6) is involved in the block of greening response in Arabidopsis thaliana
Alameldin, Hussien F.
Oh, Sookyung
Hernandez, Alexandra P.
Montgomery, Beronda L.
AMERICAN JOURNAL OF BOTANY, 2020, 107 (02) : 329 - 338
[23] Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease
Powell, Christopher A.
Nicholls, Thomas J.
Minczuk, Michel
FRONTIERS IN GENETICS, 2015, 6
[24] INA complex links assembly of the nuclear- and mitochondrial-encoded modules of ATP synthase.
Naumenko, N.
Rehling, P.
MOLECULAR BIOLOGY OF THE CELL, 2016, 27
[25] cDNA, genomic sequence cloning and overexpression of giant panda (Ailuropoda melanoleuca) mitochondrial ATP synthase ATP5G1
Hou, W. -R.
Hou, Y. -L.
Ding, X.
Wang, T.
GENETICS AND MOLECULAR RESEARCH, 2012, 11 (03) : 3164 - 3174
[26] MOLECULAR-CLONING OF A CDNA FOR THE SMALLEST NUCLEAR-ENCODED SUBUNIT OF SWEET-POTATO CYTOCHROME-C-OXIDASE - ANALYSIS WITH THE CDNA OF THE STRUCTURE AND IMPORT INTO MITOCHONDRIA OF THE SUBUNIT
NAKAGAWA, T
MAESHIMA, M
NAKAMURA, K
ASAHI, T
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 191 (03): : 557 - 561
[27] Total synthesis of human and rat coupling factor-6 amide and pressor effects in the rat
Chang, JK
Scruggs, P
Yang, J
Ouyang, M
Duetzmann, A
Dun, NJ
REGULATORY PEPTIDES, 2003, 113 (1-3) : 63 - 69
[28] High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
Brenda Gonzalez
Archana Tare
Seungjin Ryu
Simon C. Johnson
Gil Atzmon
Nir Barzilai
Matt Kaeberlein
Yousin Suh
GeroScience, 2023, 45 : 311 - 330
[29] High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
Gonzalez, Brenda
Tare, Archana
Ryu, Seungjin
Johnson, Simon C.
Atzmon, Gil
Barzilai, Nir
Kaeberlein, Matt
Suh, Yousin
GEROSCIENCE, 2023, 45 (01) : 311 - 330
[30] Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Kadkhodaei, Banafsheh
Alvarsson, Alexandra
Schintu, Nicoletta
Ramskold, Daniel
Volakakis, Nikolaos
Joodmardi, Eliza
Yoshitake, Takashi
Kehr, Jan
Decressac, Mickael
Bjorklund, Anders
Sandberg, Rickard
Svenningsson, Per
Perlmann, Thomas
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (06) : 2360 - 2365

← 1 2 3 4 5 →