Risk factors for cardiovascular disease: does a role for homocysteine still exist?

被引：6

作者：

Bendini, Maria Grazia ^{[1
]}

Lanza, Gaetano Antonio ^{[2
]}

Mazza, Andrea ^{[1
]}

Giordano, Andrea ^{[3
]}

Leggio, Massimo ^{[4
]}

Menichini, Giulio ^{[5
]}

De Cristofaro, Raffaele ^{[1
]}

Moriconi, Emanuela ^{[5
]}

Cozzari, Laura ^{[1
]}

Farina, Sergio Maria ^{[1
]}

Giordano, Giampiero ^{[1
]}

机构：

[1] Osped S Maria della Stella, UO Cardiol, Orvieto, TR, Italy

[2] Univ Cattolica Sacro Cuore, Ist Cardiol, Rome, Italy

[3] Osped S Maria della Stella, UO Nefrol, Orvieto, TR, Italy

[4] Osped San Filippo Neri, UO Riabilitaz Cardiovasc, Rome, Italy

[5] Osped S Maria della Stella, Med & Chirurg Accettaz & Urgenza, Orvieto, TR, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2007年 / 8卷 / 03期

关键词：

Atherosclerosis; Cardiovascular diseases; Homocysteine; Vitamins;

D O I：

10.1714/678.7897

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases are commonly related to classical risk factors, but other risk markers have been identified, including homocysteine. Homocysteine is a sulphurated amino acid which derives from methionine. The causes of hyperhomocysteinemia are multifactorial, such as genetic defects, pathophysiological conditions, lifestyle and drugs-related. Hyperhomocysteinemia favors atherothrombosis through endothelial dysfunction, enhancement of inflammation and thrombophilic profile. A number of clinical and laboratory trials exist regarding the association between homocysteine levels and an increased risk of cardiovascular disease. However, the lack of homogeneity in the data, together with the high number of factors capable of influencing homocysteine plasma levels, and the disappointing results of therapeutic trials do not permit us at present to consider homocysteine as an independent and major risk factor for cardiovascular disease.

引用

页码：148 / 160

页数：13

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