LABETALOL ANALYSIS IN HUMAN-PLASMA USING LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION - APPLICATION TO PHARMACOKINETIC STUDIES

被引:12
|
作者
ABERNETHY, DR [1 ]
TODD, EL [1 ]
EGAN, JL [1 ]
CARRUM, G [1 ]
机构
[1] BAYLOR COLL MED, INST LIPID RES, HOUSTON, TX 77030 USA
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1986年 / 9卷 / 10期
关键词
D O I
10.1080/01483918608074140
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Labetalol determination in human plasma by a sensitive (to 2.5 ng/ml) and selective method using liquid chromatography with electrochemical detection is described. Plasma is extracted with diethyl ether under mildly basic (pH 9) conditions, back-extracted into an aqueous acidic buffer, then injected directly on column. Standard curves using propranolol as an internal standard are linear for concentrations from 2.5 to 200 ng/ml. Within-day and between-day reproducibility is satisfactory with coefficient of variation less than 8% for all concentrations. Sample recovery from the extraction is complete at all concentrations. Utility of the method is demonstrated by a pharmacokinetic study in a hypertensive volunteer who received 43.75 mg labetalol by 10 minute intravenous infusion.
引用
收藏
页码:2153 / 2164
页数:12
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