ACTIONS AND INTERACTIONS OF GLUCOCORTICOIDS AND TRANSFORMING GROWTH-FACTOR -BETA ON 2 RELATED HUMAN MYELOMA CELL-LINES

被引：0
|
作者：
JOHNSON, BH
GOMI, M
JAKOWLEW, SB
MORIWAKI, K
THOMPSON, EB
机构：
[1] UNIV TEXAS, MED BRANCH, DEPT HUMAN BIOL CHEM & GENET, F-45, GALVESTON, TX 77550 USA
[2] OSAKA UNIV, SCH MED, DEPT INTERNAL MED 2, OSAKA 553, JAPAN
[3] NCI, CHEMOPREVENT LAB, BETHESDA, MD 20892 USA
来源：
CELL GROWTH & DIFFERENTIATION | 1993年 / 4卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
To evaluate possible involvement of a paracrine/autocrine inhibitory growth factor in myeloma cell growth, we studied the expression and actions of two forms of transforming growth factor beta (TGF-beta1 and TGF-beta2) on two closely related myeloma cell lines, OPM-1 and OPM-2. Earlier studies showed that both cell lines contain glucocorticoid receptors, but only OPM-2 cells are growth inhibited by dexamethasone (Dex). We found that OPM-2 growth was inhibited by TGF-beta, with TGF-beta1 exerting a greater effect than TGF-beta2, and Dex plus TGF-beta1 acting synergistically. In OPM-1 (Dex insensitive), TGF-beta mRNA was not expressed, whereas it was induced by Dex in OPM-2. It was also possible to block partially the growth inhibition of Dex in OPM-2 cells by the addition of anti-TGF-beta1 antibodies. These data suggest that the glucocorticoid effect(s) on myeloma cells may be mediated at least in part through modulation of internal and/or external levels of TGF-beta1.
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页码：25 / 30
页数：6
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