INVITRO ACTIVITY OF PYRONARIDINE AGAINST AFRICAN STRAINS OF PLASMODIUM-FALCIPARUM

被引：25
|
作者：
BASCO, LK
LEBRAS, J
机构：
[1] Centre National de Reference, Inst Medecine/Lab de Parasitologie, Hopital Bichat-Claude Bernard
来源：
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1992年 / 86卷 / 05期
关键词：
D O I：
10.1080/00034983.1992.11812693
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The in vitro activity of pyronaridine was determined and compared with the activity of monodesethylamodiaquine and amopyroquine against 31 clinical isolates and two clones of Plasmodium falciparum originating from Central and West Africa using a semi-micro drug susceptibility test. Pyronaridine and amopyroquine were 2.5 and four times less active, respectively, against the highly chloroquine-resistant clone, than against the chloroquine-susceptible clone but were equally active against chloroquine-susceptible and chloroquine-resistant clinical isolates. Compared with chloroquine-susceptible isolates, monodesethylamodiaquine was three times less active against chloroquine-resistant parasites. Pyronaridine is highly active against chloroquine-resistant strains of P. falciparum and may be a promising candidate for the treatment of resistant malaria.
引用
收藏
页码：447 / 454
页数：8
相关论文
共 50 条
  • [31] ANALOGS OF N-BENZYLOXYDIHYDROTRIAZINES - INVITRO ANTIMALARIAL ACTIVITY AGAINST PLASMODIUM-FALCIPARUM
    CHILDS, GE
    LAMBROS, C
    [J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1986, 80 (02): : 177 - 181
  • [32] IN-VITRO ACTIVITY OF ATOVAQUONE AGAINST THE AFRICAN ISOLATES AND CLONES OF PLASMODIUM-FALCIPARUM
    BASCO, LK
    RAMILIARISOA, O
    LEBRAS, J
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (04): : 388 - 391
  • [33] PLASMODIUM-FALCIPARUM GAMETOCYTOGENESIS INVITRO
    SMALLEY, ME
    [J]. NATURE, 1976, 264 (5583) : 271 - 272
  • [34] POSITIVE RELATIONSHIP BETWEEN THE RESPONSE OF PLASMODIUM-FALCIPARUM TO CHLOROQUINE AND PYRONARIDINE
    WARSAME, M
    WERNSDORFER, WH
    PAYNE, D
    BJORKMAN, A
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) : 570 - 571
  • [35] In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax
    Price, R. N.
    Marfurt, J.
    Chalfein, F.
    Kenangalem, E.
    Piera, K. A.
    Tjitra, E.
    Anstey, N. M.
    Russell, B.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (12) : 5146 - 5150
  • [36] POTENTIATION OF MONODESETHYLAMODIAQUINE AND AMOPYROQUINE WITH DESIPRAMINE AGAINST PLASMODIUM-FALCIPARUM INVITRO
    BASCO, LK
    LEBRAS, J
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (04) : 447 - 448
  • [37] EFFECT OF MEMBRANE FILTRATION OF ANTIMALARIAL DRUG SOLUTIONS ON INVITRO ACTIVITY AGAINST PLASMODIUM-FALCIPARUM
    BAIRD, JK
    LAMBROS, C
    [J]. BULLETIN OF THE WORLD HEALTH ORGANIZATION, 1984, 62 (03) : 439 - 444
  • [38] ACTIVITY OF CHLOROQUINE AND DESFERRIOXAMINE INVITRO AGAINST NEWLY ISOLATED PLASMODIUM-FALCIPARUM AND THEIR ANTAGONISM IN COMBINATION
    JAMBOU, R
    GHOGOMU, NA
    KOUKABEMBA, D
    HENGY, C
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1992, 86 (01) : 11 - 11
  • [39] IN-VITRO ACTIVITY OF ARTEMISININ DERIVATIVES AGAINST AFRICAN ISOLATES AND CLONES OF PLASMODIUM-FALCIPARUM
    BASCO, LK
    LEBRAS, J
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 49 (03): : 301 - 307
  • [40] VACCINES AGAINST PLASMODIUM-FALCIPARUM
    COPPEL, RL
    [J]. ISI ATLAS OF SCIENCE-IMMUNOLOGY, 1988, 1 (02): : 138 - 142
12345