INVITRO ACTIVITY OF PYRONARIDINE AGAINST AFRICAN STRAINS OF PLASMODIUM-FALCIPARUM

被引：25
|
作者：
BASCO, LK
LEBRAS, J
机构：
[1] Centre National de Reference, Inst Medecine/Lab de Parasitologie, Hopital Bichat-Claude Bernard
来源：
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1992年 / 86卷 / 05期
关键词：
D O I：
10.1080/00034983.1992.11812693
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The in vitro activity of pyronaridine was determined and compared with the activity of monodesethylamodiaquine and amopyroquine against 31 clinical isolates and two clones of Plasmodium falciparum originating from Central and West Africa using a semi-micro drug susceptibility test. Pyronaridine and amopyroquine were 2.5 and four times less active, respectively, against the highly chloroquine-resistant clone, than against the chloroquine-susceptible clone but were equally active against chloroquine-susceptible and chloroquine-resistant clinical isolates. Compared with chloroquine-susceptible isolates, monodesethylamodiaquine was three times less active against chloroquine-resistant parasites. Pyronaridine is highly active against chloroquine-resistant strains of P. falciparum and may be a promising candidate for the treatment of resistant malaria.
引用
收藏
页码：447 / 454
页数：8
相关论文
共 50 条
  • [1] INVITRO ACTIVITY OF ARTEMISININ, ITS DERIVATIVES, AND PYRONARIDINE AGAINST DIFFERENT STRAINS OF PLASMODIUM-FALCIPARUM
    ALIN, MH
    BJORKMAN, A
    ASHTON, M
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (05) : 635 - 637
  • [2] INVITRO ACTIVITY OF PYRONARIDINE AGAINST FIELD ISOLATES AND REFERENCE CLONES OF PLASMODIUM-FALCIPARUM
    CHILDS, GE
    HAUSLER, B
    MILHOUS, W
    CHEN, C
    WIMONWATTRAWATEE, T
    POOYINDEE, N
    BOUDREAU, EF
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 38 (01): : 24 - 29
  • [3] INVITRO ACTIVITY OF CHLOROQUINE, THE 2 ENANTIOMERS OF CHLOROQUINE, DESETHYLCHLOROQUINE AND PYRONARIDINE AGAINST PLASMODIUM-FALCIPARUM
    FU, S
    BJORKMAN, A
    WAHLIN, B
    OFORIADJEI, D
    ERICSSON, O
    SJOQVIST, F
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 22 (01) : 93 - 96
  • [4] INVITRO ACTIVITY OF CYCLOGUANIL AGAINST AFRICAN ISOLATES OF PLASMODIUM-FALCIPARUM
    BASCO, LK
    RAMILIARISOA, O
    RINGWALD, P
    DOURY, JC
    LEBRAS, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) : 924 - 925
  • [5] INVITRO CULTIVATION OF SOUTHERN AFRICAN STRAINS OF PLASMODIUM-FALCIPARUM AND GAMETOCYTOGENESIS
    FREESE, JA
    SHARP, BL
    RIDL, FC
    MARKUS, MB
    [J]. SOUTH AFRICAN MEDICAL JOURNAL, 1988, 73 (12): : 720 - 722
  • [6] Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro
    Elueze, EI
    Croft, SL
    Warhurst, DC
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (03) : 511 - 518
  • [7] INVITRO ACTIVITY OF MONODESETHYLAMODIAQUINE AND AMOPYROQUINE AGAINST AFRICAN ISOLATES AND CLONES OF PLASMODIUM-FALCIPARUM
    BASCO, LK
    LEBRAS, J
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (01): : 120 - 125
  • [8] ACTIVITY OF FLUOROQUINOLONE ANTIBIOTICS AGAINST PLASMODIUM-FALCIPARUM INVITRO
    DIVO, AA
    SARTORELLI, AC
    PATTON, CL
    BIA, FJ
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (08) : 1182 - 1186
  • [9] THE ACTIVITY INVITRO OF CYCLOGUANIL AND PYRIMETHAMINE IN COMBINATION AGAINST PLASMODIUM-FALCIPARUM
    YEO, AET
    RIECKMANN, KH
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1992, 86 (03) : 234 - 234
  • [10] COMPARISON OF THE RELATIVE INVITRO ACTIVITY OF CHLOROQUINE AND AMODIAQUINE AGAINST CHLOROQUINE-SENSITIVE STRAINS OF PLASMODIUM-FALCIPARUM
    EKWEOZOR, C
    ADEROUNMU, AF
    SODEINDE, O
    [J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1987, 81 (02): : 95 - 99
12345