A NOVEL HUMAN HOMOLOG OF A DEAD-BOX RNA HELICASE FAMILY

被引：12

作者：

KITAJIMA, Y ^{[1
]}

YATSUKI, H ^{[1
]}

ZHANG, R ^{[1
]}

MATSUHASHI, S ^{[1
]}

HORI, K ^{[1
]}

机构：

[1] SAGA MED SCH, DEPT BIOCHEM, SAGA 849, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Putative cDNA clones for a nuclear antigen that crossreacts with anti-human aldolase A monoclonal antibody MAb1A2 were isolated from the HeLa lambda gt11 cDNA library and a candidate clone (clone 3) was analyzed. The cDNA has an open reading frame (ORF) of 1,317 bp encoding a novel RNA helicase belonging to the DEAD RNA helicase family. The ORF also contains a nuclear targeting signal and the epitope for MAb1A2, The putative RNA helicase has sequence similarity to Escherichia coli RNA helicase DEAD, mouse translation factor eIF-4A, and human p68 and p54. (C) 1994 Academic Press, Inc.

引用

页码：748 / 754

页数：7

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