DEGRADATION OF THYROTROPIN-RELEASING-HORMONE AND LUTEINIZING-HORMONE-RELEASING HORMONE BY ENZYMES OF BRAIN-TISSUE

被引：92
|
作者：
OCUINN, G [1 ]
OCONNOR, B [1 ]
ELMORE, M [1 ]
机构：
[1] NATL UNIV IRELAND UNIV COLL GALWAY, DEPT BIOCHEM, GALWAY, IRELAND
来源：
JOURNAL OF NEUROCHEMISTRY | 1990年 / 54卷 / 01期
关键词：
Endopeptidase‐24.15; Luteinising hormone; Microsomes; Pyroglutamate aminopeptidase II; releasing hormone; Synaptosomes; Thyrotropin‐releasing hormone;
D O I：
10.1111/j.1471-4159.1990.tb13276.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract: In this article, the enzymes of brain and associated tissues that can degrade thyrotropin‐releasing hormone (TRH) and luteinising hormone‐releasing hormone (LH‐RH) are reviewed. As both TRH and LH‐RH are considered to act as neurotransmitters or neuromodulators in the CNS, attention is paid to the subcellular location of the enzymes described and how their topographies and substrate specificities fit them to playing roles as inactivating agents for TRH and LH‐RH or as regulators of intracellular concentrations of TRH and LH‐RH. Consideration is also given to enzymes involved in biotransformation of TRH to secondary metabolites that exhibit biological activity and to enzymes involved in the metabolism of secondary metabolites. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：1 / 13
页数：13
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