EFFECT OF INTRAPERITONEALLY ADMINISTERED BETA-1,3-GLUCAN, SSG, OBTAINED FROM SCLEROTINIA-SCLEROTIORUM IFO-9395 ON THE FUNCTIONS OF MURINE ALVEOLAR MACROPHAGES

被引：0
|
作者：
SAKURAI, T
SUZUKI, I
KINOSHITA, A
OIKAWA, S
MASUDA, A
OHSAWA, M
YADOMAE, T
机构：
[1] TOKYO COLL PHARM, HORINOUCHI 1432-1, HACHIOJI, TOKYO 19203, JAPAN
[2] NIPPON BEET SUGAR MFG CO LTD, CHUO KU, TOKYO 104, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of intraperitoneally (i.p.) administered SSG, a beta-1,3-glucan obtained from the culture filtrate of the fungus Sclerotinia sclerotiorum IFO 9395, on the functions of alveolar macrophages (AM) in CDF1 mice was examined. SSG administered i.p. increased the number of AM and enhanced several functions of murine AM (lysosonal enzyme activity, phagocytic activity, candidacidal activity, H2O2 production and interleukin 1 (IL-1) production) at a dose of 250-mu-g/mouse on days 1 and 8, especially on day 8. Furthermore, SSG (250-mu-g/mouse) administered i.p. for 10 consecutive days significantly inhibited the experimental pulmonary metastasis of Lewis Lung Carcinoma (3LL) on BDF1 mice.
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页码：214 / 217
页数：4
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