FORMULATION DEVELOPMENT AND EVALUATION OF BUCCAL TABLETS OF PANTOPRAZOLE

被引：0
|
作者：
Mounika, B. [1 ]
Mahesh, M. [1 ]
Preethi, M. [1 ]
Sravani, P. [1 ]
Sarojini, S. [2 ]
Dutt, K. Rajeswar [3 ]
机构：
[1] Nalanda Coll Pharm, Dept Pharmaceut, Nalgonda, Telangana, India
[2] Nalanda Coll Pharm, Dept Ind Pharm, Nalgonda, Telangana, India
[3] Nalanda Coll Pharm, Dept Pharmaceut Anal & QA, Nalgonda, Telangana, India
来源：
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 04期
关键词：
Buccal; Protonix; Bioadhesive; Systemic circulation; Half life;
D O I：
10.5281/zenodo.1215689
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of present work is to formulate and evaluate buccal tablets of protonix (pantoprazole sodium) which is subjected to first pass effect and having short half life. To increase the bio availability of a protonix by delivering through the buccal mucosa, as it is a potential site for direct delivery of drugs into systemic circulation. To control the drug release from the tablets by using matrix forming bioadhesive polymers, as the half life of drug is very low. To study the effect of drug : polymer ratio on drug release and other bioadhesive properties.
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页码：2238 / 2243
页数：6
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