INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN EXPRESSION IN HUMAN SMALL-CELL LUNG-CANCER CELL-LINES

被引：14
|
作者：
KIEFER, P
JAQUES, G
SCHONEBERGER, J
HEINRICH, G
HAVEMANN, K
机构：
[1] UNIV MARBURG,MED CTR,DIV HEMATOL ONCOL,W-3550 MARBURG,GERMANY
[2] SANDOZ LTD,PRECLIN RES,DEPT BIOTECHNOL,CH-4002 BASEL,SWITZERLAND
来源：
EXPERIMENTAL CELL RESEARCH | 1991年 / 192卷 / 02期
关键词：
D O I：
10.1016/0014-4827(91)90059-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Insulin-like growth factor binding proteins (IGF-BP) are secreted by several human small cell lung cancer cell lines (SCLC). In order to identify the IGF-BPs from SCLC cell lines the RNA from 10 different SCLC cell lines was analyzed by Northern blot analysis with the probes for three different IGF-BPs, IGFBP-1, IGFBP-2, and IGFBP-3. No hybridization signal could be detected with the probes encoding for IGFBP-1 and IGFBP-3. The hybridization with different IGFBP-2-specific oligodeoxynucleotide probes and with the corresponding full-length cDNA showed that all SCLC cell lines which secreted IGF-BPs express IGFBP-2. © 1991.
引用
收藏
页码：414 / 417
页数：4
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