SYNTHESIS AND ANALYSIS OF 1,2,3,4-TETRAHYDRO-(9H)-PYRIDO[3,4-B]INDOLE

被引：12

作者：

RODRIGUEZ, JG

GILLOPETEGUI, P

机构：

[1] Departamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 02期

关键词：

D O I：

10.1002/jhet.5570300214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1,2,3,4-tetrahydro-(9H)-pyrido[3,4-b]indole derivatives was carried out in one pot, by condensation of tryptamin with cycloalkanones in the presence of a polyphosphate ester as the catalyst in moderate to low yields, the aldol condensation being the main products. Reaction of tryptamine and cyclic ketones was also carried out in two stage through the imine intermediate with protic catalysis giving the tetrahydro-beta-carbolines 8-14, in good yields. 2-Methyl derivatives 15-21, of the tetrahydro-beta-carbolines, were obtained in good yields, using methyl iodide in dimethyl sulphoxide-potassium carbonate.

引用

页码：373 / 378

页数：6

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