THE USE OF MONOCLONAL-ANTIBODIES TO ACHIEVE IMMUNOLOGICAL-TOLERANCE

被引：12
|
作者：
WALDMANN, H
COBBOLD, S
机构：
[1] Department of Pathology, Cambridge, CB2 1QP, Tennis Court Road
[2] Department of Pathology, Cambridge, CB2 1QP, Tennis Court Road
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0165-6147(93)90198-S
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming, reviewed by Herman Waldmann and Stephen Cobbold, is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.
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页码：143 / 148
页数：6
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