SYNTHESIS AND ANTITUBERCULOSIS ACTIVITY OF BENZOTHIENO[2,3-D]PYRIMIDINE

被引：0
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作者：
KAPUSTINA, MV
AMELKIN, OY
KHARIZOMENOVA, IA
SHVEDOV, VI
FILITIS, LN
机构：
来源：
KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1991年 / 25卷 / 07期
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中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bifunctional derivatives of benzothieno[2,3-d]pyrimidine have been synthesized and tested for antituberculous activity. 7-Bromo-8-hydroxy-2,3-trimethylene-4-oxy-3,4-dihydrobenzothieno[2,3-d]pyrimidine and 2-amino-3-ethoxycarbonyl-6-bromo-7-hydroxybenzo(b)thiophene were found to have tuberculostatic activity, whereas 7-bromo-8-hydroxy-2,3-pentamethylene-4-oxy-3,4-dihydrobenzothieno[2,3-d]pyrimidine, 7-bromo-8-hydroxy-2,3-(tetramethylene-2-oxa)-4-oxy-3,4-dihydrobenzothieno[2,3-d]-pyrimidine, 7-bromo-8-methoxy-4-oxy-3,4 - dihydrobenzothieno-[2,3-d]pyrimidine, and 7-bromo-8-benzyloxy-4-oxy-3,4-dihydrobenzothieno[2,3-d]pyrimidine were devoid of antituberculous activity.
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页码：38 / 39
页数：2
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