COINCIDENT INDEXES OF EXONS AND INTRONS

被引：4
|
作者：
XU, J [1 ]
CHEN, RS [1 ]
LING, LJ [1 ]
SHEN, RQ [1 ]
SUN, J [1 ]
机构：
[1] ACAD SINICA, INST BIOPHYS, BEIJING 100101, PEOPLES R CHINA
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 1993年 / 23卷 / 04期
关键词：
COINCIDENT INDEX; CRYPTOLOGY; DNA SEQUENCE ANALYSIS; EXON PREDICTION;
D O I：
10.1016/0010-4825(93)90088-I
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this paper, the coincident index, proposed by W. F. Friedman in cryptology, is made use of in DNA sequence analysis and exon prediction. The coincident index of exons exceeds that of introns by many times, and is mainly affected by window length, which is correlated negatively with the coincident index. An optimal exon prediction scheme was obtained by experimental analysis with an orthogonal table. Besides exons, many other special sites such as tandem repeats can be identified by using the coincident index approach. The application of this approach to the ARV-2 (AIDS associated retrovirus 2) genome found three new possible coding regions and some unusual base composition regions which are probably related to definite biological functions.
引用
收藏
页码：333 / 343
页数：11
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