METHOTREXATE FOR ABORTION AT LESS-THAN-OR-EQUAL-TO-42 DAYS GESTATION

被引：32

作者：

CREININ, MD

机构：

[1] Department of Obstetrics, Gynecology and Reproductive Sciences University of California, San Francisco San Francisco General Hospital

来源：

CONTRACEPTION | 1993年 / 48卷 / 06期

关键词：

MEDICAL ABORTION; METHOTREXATE; BETA-HCG; VAGINAL ULTRASOUND;

D O I：

10.1016/0010-7824(93)90114-M

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Methotrexate is cytotoxic to trophoblast and, in low doses, has minimal side effects. It is used to treat gestational trophoblastic neoplasia and ectopic pregnancy and has recently been shown to have similar effects on intrauterine trophoblast. A prior study suggested that methotrexate may successfully cause abortion of an early pregnancy without prostaglandin. To test this hypothesis, ten pregnant women at less than or equal to 42 days gestation were treated with methotrexate 50 mg/m(2) intramuscularly. Vaginal bleeding started 24 +/- 20 (mean +/- standard deviation) days after the injection and lasted 10 +/- 3 days. Methotrexate side effects occurred in 4 patients and were limited to the first 4 days after the injection. Methotrexate alone appears sufficient to abort a very early intrauterine pregnancy.

引用

页码：519 / 525

页数：7

共 50 条

[21] LESS THAN OR EQUAL TO AN EXERCISE
FLANDERS, H
AMERICAN MATHEMATICAL MONTHLY, 1979, 86 (07): : 583 - 584
[22] AN ATOMIC MASS STUDY OF NUCLEAR SHELL STRUCTURE IN THE REGION 28-LESS-THAN-OR-EQUAL-TO-N-LESS-THAN-OR-EQUAL-TO-50 AND 28-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-40
HOGG, BG
DUCKWORTH, HE
CANADIAN JOURNAL OF PHYSICS, 1953, 31 (06) : 942 - 953
[23] LESS EQUAL THAN OTHERS
Meer, Nasar
INDEX ON CENSORSHIP, 2007, 36 (02) : 114 - 118
[24] CONCERNING THE SOLUTION SET OF AX=B WHERE P LESS-THAN-OR-EQUAL-TO A LESS-THAN-OR-EQUAL-TO Q AND P LESS-THAN-OR-EQUAL-TO B LESS-THAN-OR-EQUAL-TO Q
HARTFIEL, DJ
NUMERISCHE MATHEMATIK, 1980, 35 (03) : 355 - 359
[25] A FORMULA FOR P(BI-LESS-THAN-OR-EQUAL-TO-RI-LESS-THAN-OR-EQUAL-TO-AI, 1-LESS-THAN-OR-EQUAL-TO-I-LESS-THAN-OR-EQUAL-TO-M) UNDER A GENERAL-CLASS OF ALTERNATIVES
HANDA, BR
MOHANTY, SG
JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 1982, 6 (04) : 335 - 343
[26] ELECTROPRODUCTION OF RHO MESONS AT 0.3 LESS THAN OR EQUAL TO Q2 LESS THAN OR EQUAL TO 1.5 GEV2 AND 1.7 LESS THAN OR EQUAL TO W LESS THAN OR EQUAL TO 2.8 GEV
ECKARDT, V
GEBAUER, HJ
JOOS, P
MEYER, H
NAROSKA, B
NOTZ, D
PODOLSKY, WJ
WOLF, G
YELLIN, S
PHYSICS LETTERS B, 1973, B 43 (03) : 240 - 244
[27] MU-RHO ALGORITHM VALID FOR 1 KEV-LESS-THAN-OR-EQUAL-TO-E-LESS-THAN-OR-EQUAL-TO-50 KEV AND 11-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-83
WERNISCH, J
POHN, C
HANKE, W
EBEL, H
X-RAY SPECTROMETRY, 1984, 13 (04) : 180 - 181
[28] MEASUREMENTS OF K-SHELL TO L-SHELL VACANCY TRANSFER PROBABILITY FOR THE ELEMENTS 37-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-42
PURI, S
MEHTA, D
CHAND, B
SINGH, N
TREHAN, PN
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1993, 73 (04): : 443 - 446
[29] OUTCOME OF INFANTS LESS-THAN-OR-EQUAL-TO-25 WKS GESTATION (1981-1985)
MARKS, KH
GIFFORD, KL
HIMMELBERGER, ES
DOMOTO, M
MAISELS, MJ
PEDIATRIC RESEARCH, 1987, 21 (04) : A399 - A399
[30] NEUROBEHAVIORAL ASSESSMENT OF WELL AND ILL PREMATURES OF LESS-THAN-OR-EQUAL-TO-32 WEEKS GESTATION
SCOTT, DT
FARWELL, JR
PEDIATRIC RESEARCH, 1977, 11 (04) : 565 - 565

← 1 2 3 4 5 →