METHOTREXATE FOR ABORTION AT LESS-THAN-OR-EQUAL-TO-42 DAYS GESTATION

被引：32

作者：

CREININ, MD

机构：

[1] Department of Obstetrics, Gynecology and Reproductive Sciences University of California, San Francisco San Francisco General Hospital

来源：

CONTRACEPTION | 1993年 / 48卷 / 06期

关键词：

MEDICAL ABORTION; METHOTREXATE; BETA-HCG; VAGINAL ULTRASOUND;

D O I：

10.1016/0010-7824(93)90114-M

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Methotrexate is cytotoxic to trophoblast and, in low doses, has minimal side effects. It is used to treat gestational trophoblastic neoplasia and ectopic pregnancy and has recently been shown to have similar effects on intrauterine trophoblast. A prior study suggested that methotrexate may successfully cause abortion of an early pregnancy without prostaglandin. To test this hypothesis, ten pregnant women at less than or equal to 42 days gestation were treated with methotrexate 50 mg/m(2) intramuscularly. Vaginal bleeding started 24 +/- 20 (mean +/- standard deviation) days after the injection and lasted 10 +/- 3 days. Methotrexate side effects occurred in 4 patients and were limited to the first 4 days after the injection. Methotrexate alone appears sufficient to abort a very early intrauterine pregnancy.

引用

页码：519 / 525

页数：7

共 50 条

[1] Serum human chorionic gonadotropin decline following aspiration abortion in early pregnancy less than 42 days gestation
Baldwin, Maureen K.
Bednarek, Paula H.
Russo, Jennefer
CONTRACEPTION, 2021, 103 (02) : 113 - 115
[2] METHOTREXATE AND MISOPROSTOL FOR ABORTION AT 57-63 DAYS GESTATION
CREININ, MD
CONTRACEPTION, 1994, 50 (06) : 511 - 515
[3] FATAL PULMONARY HYPOPLASIA WITHIN 17 DAYS OF SEVERE OLIGOHYDRAMNIOS -LESS-THAN-OR-EQUAL-TO-28 WEEKS GESTATION
KILBRIDE, HW
THIBEAULT, DW
YEAST, J
MAULIK, D
MEADE, V
GRUNDY, HO
PEDIATRIC RESEARCH, 1987, 21 (04) : A456 - A456
[4] Comparison of medication abortion outcomes at less than and greater than 6 weeks gestation
Dethier, Divya
Soon, Reni
Ronquillo, Taylor
Wong, Zarina
Tschann, Mary
CONTRACEPTION, 2024, 140
[5] SHAPE COEXISTENCE EFFECTS OF SUPERDEFORMED AND HYPERDEFORMED CONFIGURATIONS IN ROTATING NUCLEI .2. NUCLEI WITH 42-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-56 AND 74-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-92
WERNER, TR
DUDEK, J
ATOMIC DATA AND NUCLEAR DATA TABLES, 1995, 59 (01) : 1 - 181
[6] COMPARING CHARACTERISTICS AND OUTCOMES OF MEDICATION ABORTION AT LESS THAN AND GREATER THAN SIX WEEKS' GESTATION
Dethier, D.
Wong, Z. J.
Ronquillo, T.
Soon, R.
Tschann, M.
CONTRACEPTION, 2023, 127 : 9 - 9
[7] Decreased respiratory compliance in infants less than or equal to 32 weeks' gestation, delivered more than 7 days after antenatal steroid therapy
McEvoy, Cindy
Schilling, Diane
Spitale, Patricia
Peters, Dawn
O'Malley, Jean
Durand, Manuel
PEDIATRICS, 2008, 121 (05) : E1032 - E1038
[8] MAGNETIC-PROPERTIES OF THE LAYERED COMPOUND LI-LESS-THAN-OR-EQUAL-TO-1.0V1-LESS-THAN-OR-EQUAL-TO-0.33FE-LESS-THAN-OR-EQUAL-TO-0.3352,LI-LESS-THAN-OR-EQUAL-TO-1.0V1-LESS-THAN-OR-EQUAL-TO-0.33CO-LESS-THAN-OR-EQUAL-TO-0.3352,LI-LESS-THAN-OR-EQUAL-TO-1.0V1-LESS-THAN-OR-EQUAL-TO-0.33NI-LESS-THAN-OR-EQUAL-TO-0.3352
DISALVO, FJ
WASZCZAK, JV
EIBSCHUTZ, M
PHYSICAL REVIEW B, 1981, 24 (09): : 5143 - 5148
[9] FLUORESCENCE YIELDS, OMEGA-K (12-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-42) AND OMEGA-L3 (38-LESS-THAN-OR-EQUAL-TO-Z-LESS-THAN-OR-EQUAL-TO-79), FROM A COMPARISON OF LITERATURE AND EXPERIMENTS (SEM)
HANKE, W
WERNISCH, J
POHN, C
X-RAY SPECTROMETRY, 1985, 14 (01) : 43 - 47
[10] ISOTOPE ABUNDANCES FOR 3 LESS-THAN-OR-EQUAL-TO Z LESS-THAN-OR-EQUAL-TO 26 AND 200 LESS-THAN-OR-EQUAL-TO E LESS-THAN-OR-EQUAL-TO 500
ARENS, JF
BULLETIN OF THE AMERICAN PHYSICAL SOCIETY, 1976, 21 (04): : 541 - 541

← 1 2 3 4 5 →