DURATION OF THE PROTECTIVE EFFECT OF POLYASPARTIC ACID ON EXPERIMENTAL GENTAMICIN-NEPHROTOXICITY

被引：9
|
作者：
SWAN, SK
GILBERT, DN
KOHLHEPP, SJ
LEGGETT, JE
KOHNEN, PW
BENNETT, WM
机构：
[1] PROVIDENCE MED CTR,DEPT INTERNAL MED & INFECT DIS,PORTLAND,OR 97213
[2] PROVIDENCE MED CTR,CHILES RES INST,PORTLAND,OR 97213
[3] PROVIDENCE MED CTR,DEPT PATHOL,PORTLAND,OR 97213
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 11期
关键词：
D O I：
10.1128/AAC.36.11.2556
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.
引用
收藏
页码：2556 / 2558
页数：3
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