REGULATION OF THE PROLIFERATION AND BIOSYNTHETIC ACTIVITIES OF CULTURED HUMAN PEYRONIES DISEASE FIBROBLASTS BY INTERFERONS-ALPHA, INTERFERONS-BETA AND INTERFERONS-GAMMA

被引：90
|
作者：
DUNCAN, MR
BERMAN, B
NSEYO, UO
机构：
[1] UNIV CALIF DAVIS,SCH MED,DEPT UROL,DAVIS,CA 95616
[2] VET AFFAIRS MED CTR,DERMATOL SERV,MARTINEZ,CA
[3] VET AFFAIRS MED CTR,SURG SERV,MARTINEZ,CA
来源：
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 1991年 / 25卷 / 02期
关键词：
PEYRONIES DISEASE; FIBROBLASTS; INTERFERONS; PROLIFERATION; COLLAGEN; COLLAGENASE;
D O I：
10.3109/00365599109024539
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
To determine the therapeutic potential of interferon (IFN) treatment for Peyronie's disease, we investigated the effect of human recombinant (hu-r) IFNs on cultured fibroblasts derived from a Peyronie's disease penile plaque. Treatment of cultured fibroblasts with hu-r-IFN-alpha-2b, hu-r-IFN-beta-ser17 and hu-r-IFN gamma caused a concentration dependent inhibition of both fibroblast proliferation and collagen production, as well as an increase in collagenase production. Hu-r-IFN-alpha and beta had no effect on fibroblast glycosaminoglycan (GAG) or fibronectin production, while hu-r-IFN-gamma markedly increased both GAG and fibronectin production. These results demonstrate that IFNs, especially IFNs-alpha and beta, exhibit antifibrotic activity on Peyronie's disease fibroblasts and suggest a rationale for using IFNs to treat Peyronie's disease.
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页码：89 / 94
页数：6
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