INTERFERON-ALPHA OR INTERFERON-BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL-LINES

被引：5
|
作者：
STANZIONE, S
CIMOLI, G
DEBERNARDIS, D
MICHELOTTI, A
CONTE, PF
PARODI, S
RUSSO, P
机构：
[1] IST NAZL RIC CANC, DEPT CHEM CARCINOGENESIS, I-16132 GENOA, ITALY
[2] OSPED SANTA CHIARA, DEPT MED ONCOL, I-56100 PISA, ITALY
来源：
MUTATION RESEARCH LETTERS | 1995年 / 348卷 / 03期
关键词：
INTERFERONS; PLATINUM; DNA DAMAGE; POTENTIATION; GLIOMA;
D O I：
10.1016/0165-7992(95)00057-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of interferon-alpha or beta on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-a increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.
引用
收藏
页码：131 / 135
页数：5
相关论文
共 50 条
  • [21] ANTIPROLIFERATIVE ACTIVITY OF INTERFERON-ALPHA ON HUMAN SQUAMOUS CARCINOMA OF TONGUE CELL-LINES
    KING, WWK
    LAM, PK
    LI, AKC
    CANCER LETTERS, 1994, 85 (01) : 55 - 58
  • [22] CONSTITUTIVE PRODUCTION OF ALPHA-INTERFERON AND BETA-INTERFERON IN MUTANT HUMAN CELL-LINES
    MCKENDRY, R
    PELLEGRINI, S
    KERR, IM
    STARK, GR
    JOURNAL OF VIROLOGY, 1994, 68 (06) : 4057 - 4062
  • [23] GROWTH INHIBITING ACTION OF INTERFERON-ALPHA AND INTERFERON-GAMMA ON MELANOMA CELL-LINES
    OSANTO, S
    HOOGENDOORN, F
    PIGMENT CELL RESEARCH, 1988, 1 (04): : 299 - 299
  • [24] INFLUENCE OF INTERFERON-ALPHA, INTERFERON-BETA AND INTERFERON-DELTA ON FIBROBLASTS ATTACHMENT AND CHEMOTAXIS
    MENSING, H
    KORNER, C
    STEINKRAUS, V
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (04) : 443 - 443
  • [25] AUGMENTATION OF ANTIPROLIFERATIVE ACTIVITY OF INTERFERON-ALPHA AGAINST HUMAN BLADDER-TUMOR CELL-LINES BY ENCAPSULATION OF INTERFERON-ALPHA WITHIN LIPOSOMES
    KILLION, JJ
    FAN, D
    BUCANA, CD
    FRANGOS, DN
    PRICE, JE
    FIDLER, IJ
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (18) : 1387 - 1392
  • [26] INTERFERON-BETA INDUCED REMISSION IN A HAIRY-CELL LEUKEMIA PATIENT RESISTANT TO INTERFERON-ALPHA
    MICHALEVICZ, R
    ADERKA, D
    FRISCH, B
    REVEL, M
    LEUKEMIA RESEARCH, 1988, 12 (10) : 845 - 851
  • [27] MECHANISMS FOR THE INHIBITION OF HIV REPLICATION BY INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA IN PRIMARY HUMAN MACROPHAGES
    MEYLAN, PRA
    GUATELLI, JC
    MUNIS, JR
    RICHMAN, DD
    KORNBLUTH, RS
    VIROLOGY, 1993, 193 (01) : 138 - 148
  • [28] HUMAN INTERFERON-ALPHA AND INTERFERON-BETA HAVE MORE POTENT PRIMING ACTIVITIES THAN INTERFERON-GAMMA
    TOTH, M
    ENDRESZ, V
    TOTH, S
    BELADI, I
    JOURNAL OF GENERAL VIROLOGY, 1985, 66 (APR): : 893 - 896
  • [29] EFFECT OF INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA ON THE INVITRO GROWTH OF HUMAN RENAL ADENOCARCINOMA CELLS
    KUEBLER, JP
    OBERLEY, TD
    MEISNER, LF
    SIDKY, YA
    REZNIKOFF, CA
    BORDEN, EC
    CUMMINGS, KB
    BRYAN, GT
    INVESTIGATIONAL NEW DRUGS, 1987, 5 (01) : 21 - 29
  • [30] ANTIGENIC LINK BETWEEN HUMAN INTERFERON-ALPHA AND INTERFERON-BETA - THE COMMON EPITOPE-1
    KONTSEK, P
    BORECKY, L
    KONTSEKOVA, E
    NOVAK, M
    KRCHNAK, V
    JOURNAL OF INTERFERON RESEARCH, 1990, 10 (02): : 119 - 128
12345