Leptin revisited: The role of leptin in starvation

被引：3
|
作者：
Perry, Rachel J. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 05期
关键词：
Starvation; Corticosterone; Lipolysis; Gluconeogenesis; Leptin; Acetyl-CoA; Systems biology studies in molecular and cellular oncology;
D O I：
10.1080/23723556.2018.1435185
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats.
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页数：2
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