Leptin revisited: The role of leptin in starvation

被引：3
|
作者：
Perry, Rachel J. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 05期
关键词：
Starvation; Corticosterone; Lipolysis; Gluconeogenesis; Leptin; Acetyl-CoA; Systems biology studies in molecular and cellular oncology;
D O I：
10.1080/23723556.2018.1435185
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats.
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Leptin's role in starvation
    Bradley, Conor A.
    NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (03) : 129 - 129
  • [2] Leptin's role in starvation
    Conor A. Bradley
    Nature Reviews Endocrinology, 2018, 14 : 129 - 129
  • [3] Leptin, starvation and the mouse gut
    Chaudhary, M
    FitzGerald, AJ
    Mandir, N
    Howard, JK
    Lord, GM
    Ghatei, MA
    Bloom, SR
    Goodlad, RA
    DIETARY ANTICARCINOGENS AND ANTIMUTAGENS, 2000, (255): : 314 - 319
  • [4] The role of leptin in leptin resistance and obesity
    Zhang, Yi
    Scarpace, Philip J.
    PHYSIOLOGY & BEHAVIOR, 2006, 88 (03) : 249 - 256
  • [5] Role of leptin and leptin receptor in inflammation
    Halle, M
    Persson, PB
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 284 (03) : R760 - R762
  • [6] Leptin inhibits the starvation responses of mice
    Speakman, JR
    Trayhurn, P
    Rayner, DV
    FASEB JOURNAL, 1999, 13 (05): : A1027 - A1027
  • [7] Selective leptin resistance revisited
    Mark, Allyn L.
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 305 (06) : R566 - R581
  • [8] Role of leptin and leptin receptors in hematological malignancies
    Uddin, Shahab
    Mohammad, Ramzi M.
    LEUKEMIA & LYMPHOMA, 2016, 57 (01) : 10 - 16
  • [9] Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity
    Muhammad Wasim
    Fazli Rabbi Awan
    Syeda Sadia Najam
    Abdul Rehman Khan
    Haq Nawaz Khan
    Biochemical Genetics, 2016, 54 : 565 - 572
  • [10] The role of leptin in obesity and the potential for leptin replacement therapy
    Feng, Helin
    Zheng, Lihua
    Feng, Zhangying
    Zhao, Yaheng
    Zhang, Ning
    ENDOCRINE, 2013, 44 (01) : 33 - 39
12345