A PRACTICAL, ONE-POT PREPARATION OF DIISOPINOCAMPHEYLCHLOROBORANE

被引：1
|
作者：
SIMPSON, P
TSCHAEN, D
VERHOEVEN, TR
机构：
[1] Merck Sharp and Dohme Research Laboratories, Division of Merck & Co., Inc., P.O. Box 2000 Rahway
来源：
SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 03期
关键词：
D O I：
10.1080/00397919108016769
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc2BCl) from a-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful for large scale operations. Asymmetric reduction of ketones using the in situ prepared Ipc2BCl is comparable to that using isolated reagent.
引用
收藏
页码：449 / 458
页数：10
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