BAY K-8644 POTENTIATES THE ANXIOLYTIC EFFECT OF ETHANOL

被引：10

作者：

KIRAC, R ^{[1
]}

EROGLU, L ^{[1
]}

机构：

[1] ISTANBUL MED FAC,DEPT PHARMACOL,ISTANBUL,TURKEY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 02期

关键词：

ETHANOL; ANXIETY; CALCIUM CHANNELS; BAY K-8644; NIFEDIPINE;

D O I：

10.1016/0091-3057(91)90187-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The possible role of voltage-sensitive calcium channels (VSCCs) in the anxiolytic effect of ethanol was investigated using three different doses of ethanol (0.5, 1.0 and 2.0 g/kg) with calcium agonist Bay K 8644 (0.5 mg/kg) and calcium antagonist nifedipine (5 mg/kg) in rats. Ethanol produced an anxiolytic effect in a dose-dependent manner. The Bay K 8644-potentiated anxiolytic effect of ethanol, however, Bay K 8644 did not alter anxiety when used alone. Nifedipine itself showed an anxiolytic effect but did not change the ethanol-induced anxiolytic effect. This finding may lead to the consideration of the neurochemical mechanisms of the anxiolytic effects of ethanol and nifedipine as they vary from each other.

引用

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页码：325 / 327

页数：3

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