2 NOVEL NORDITERPENOID ALKALOIDS FROM DELPHINIUM-STAPHISAGRIA

Two novel norditerpenoid alkaloids, staphisadrine [1] and staphisadrinine [2], have been isolated from Delphinium staphisagria. Structures 1 and 2 were determined from physical and spectroscopic data, including DEPT and nOe difference experiments. Staphisadrine [1] is the first example of an aconitine-type alkaloid bearing a formyl group on C-4. Staphisadrinine [2] is the first norditerpenoid alkaloid that possesses a carbonyl function on C-16. Two known norditerpenoid alkaloids, pyrodelphinine [3] and l4-acetyl-l-epi-neoline [4], were also isolated and have not been previously reported as natural products. © 1990, American Chemical Society. All rights reserved.