ASYMMETRIC-SYNTHESIS OF THE ANTICOCCIDIAL ANTIBIOTIC DIOLMYCIN-A1 - DETERMINATION OF ABSOLUTE STEREOCHEMISTRY

被引：11
|
作者：
SUNAZUKA, T
TABATA, N
NAGAMITSU, T
TOMODA, H
OMURA, S
SMITH, AB
机构：
[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN
[2] MONELL CHEM SENSES CTR,DEPT CHEM,PHILADELPHIA,PA 19104
[3] UNIV PENN,RES STRUCT MATTER LAB,PHILADELPHIA,PA 19104
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 42期
关键词：
D O I：
10.1016/S0040-4039(00)61668-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric total synthesis of diolmycin A1 (1), a recently discovered anticoccidial antibiotic, has been achieved in six steps from 2-(4-hydroxyphenyl)ethanol. The natural product comprises an unusual ca. 4:1 mixture of enantiomers; the synthesis defined the (11R,12S) absolute configuration of the predominant (-) antipode.
引用
收藏
页码：6659 / 6660
页数：2
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