STUDIES ON CARDIOTONIC AGENTS .6. SYNTHESIS OF NOVEL 4,5-DIHYDRO-3(2H)-PYRIDAZINONE DERIVATIVES CARRYING SOME BENZOHETEROCYCLES AT THE 6-POSITION

被引：0

作者：

NOMOTO, Y

TAKAI, H

OHNO, T

KUBO, K

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 02期

关键词：

CARDIOTONIC AGENT; STRUCTURE ACTIVITY RELATIONSHIP; PYRIDAZINONE; QUINAZOLINE; BENZOTHIAZOLE; IMIDAZOBENZOTHIAZOLE; BENZOTHIOPHENE; BENZOTHIENOPYRIMIDINE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several benzothiazolyl, imidazobenzothiazolyl, benzothienyl, benzothienopyrimidinyl and quinazolinyl 4,5-dihydro-3(2H)-pyridazinones were synthesized and examined for cardiotonic activity in anesthetized dogs after i.v. administration. Among them, 4-methylamino-7-(2,3,4,5-tetrahydro-5-methyl-3-oxo-6-pyridazinyl)quinazoline (36) showed potent and long-lasting inotropic activity (relative potency = 2.11, milrinone = 1). The activity of 36 was more potent that indolidan (2) (relative potency = 1.53) which is one of the most potent inotropic agents to date.

引用

页码：352 / 357

页数：6

共 50 条

[31] EFFECTS OF 6-[PARA-(4-PHENYLACETYLPIPERAZIN-1-YL)PHENYL]-4,5-DIHYDRO-3(2H)PYRIDAZINONE (CCI-17810) AND ASPIRIN ON PLATELET-AGGREGATION AND ADHESIVENESS
GRIFFETT, EM
KINNON, SM
KUMAR, A
LECKER, D
SMITH, GM
TOMICH, EG
BRITISH JOURNAL OF PHARMACOLOGY, 1981, 72 (04) : 697 - 705
[32] SYNTHESIS AND EVALUATION OF SOME 4,5-DISUBSTITUTED 6-PHENYL-3(2H)-PYRIDAZINONES AS HYPOTENSIVE AGENTS
DALPIAZ, V
GIOVANNONI, MP
LAGUNA, R
CANO, E
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1994, 29 (03) : 249 - 252
[33] SYNTHESIS AND REACTIONS OF 6-ARYL-4-(3,5-DIMETHYLPYRAZOL-1-YL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONES AND THE STUDY OF THEIR ANTIBACTERIAL AND MOLLUSCICIDAL ACTIVITIES
SAYED, GH
YOUSIF, NM
SHIBA, SA
MOHAMED, SM
FLEFEL, IM
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 1992, 14 (02): : 125 - 132
[34] SYNTHESIS OF SOME 2-(2-BENZOTHIAZOLYL) AND 2-(2-BENZIMIDAZOLYL)-6-ARYL-4, 5-DIHYDRO-3(2H)-PYRIDAZINONES AS POTENTIAL ANTIINFLAMMATORY AGENTS
SAWHNEY, SN
BHUTANI, S
VIR, D
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1987, 26 (04): : 348 - 350
[35] ANTIHYPERTENSIVE AND ANTITHROMBOTIC ACTIVITIES OF 6-(SUBSTITUTED PHENYL)-5-HYDROXYMETHYL-4,5-DIHYDRO-3(2H)PYRIDAZINONES
BARLOCCO, D
MARTINI, A
PINNA, GA
CURZU, MM
SALA, F
GERMINI, M
FARMACO-EDIZIONE SCIENTIFICA, 1987, 42 (08): : 585 - 594
[36] Synthesis of 11H-indolo[3,2-c]quinoline derivatives carrying a substituent at the 6-position
Kobayashi, K. (kkoba@chem.tottori-u.ac.jp), 1600, Chemical Society of Japan (78):
[37] CRYSTAL-STRUCTURE OF 4,5-DIHYDRO-6-(2-THIENYL)-3(2H)PYRIDAZINONE AZINE, C16H16N6S2
WILL, G
FARAG, ISA
ELKORDY, M
ACTA CRYSTALLOGRAPHICA SECTION A, 1984, 40 : C285 - C285
[38] SYNTHESIS AND REACTION OF 6(9'-ANTHRACENYL)-3(2H)-PYRIDAZINONE DERIVATIVES AND STUDY OF THEIR MICROBIOLOGICAL ACTIVITY
YASSIN, FA
ELFARARGY, AF
ELMOBAYED, MM
ELKADY, MY
ELMAKSOUD, MRA
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 1991, 13 (04): : 267 - 272
[39] 2-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone Synthon for Some New Annelated 1,2,3-Selena/Thiadiazoles and 2H-Diazaphospholes with Anticipated Biological Activity and Quantum Chemical Calculations
El-Shamy, I. E.
Hleli, E.
El-Hashash, M. A.
Kelnar, I.
Abdel-Mohsen, A. M.
MOLECULES, 2023, 28 (03):
[40] 6-(SUBSTITUTED PHENYL)-5-SUBSTITUTED-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - ANTIHYPERTENSIVE AGENTS
MCEVOY, FJ
ALLEN, GR
JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) : 281 - 286

← 1 2 3 4 5 →