ANTIOXIDANT AND ANTIHYPERLIPIDAEMIC ACTIVITY FOR METHANOLIC EXTRACT OF NYCTANTHES ARBORTRISTIS LEAVES

Objective: The present study was to evaluate the antihyperlipidemic activity for methanolic extract of Nyctanthes arbor-tristis (Linn.) leaves. Methodology: Methanolic extract of Nyctathes arbor-tristis (MENA) was evaluated for in vitro antioxidant assay by reducing power assay and hydrogen peroxide assay and in vivo models of antihyperlipidemic study was carried out by 3 methods those are cholesterol diet, triton 100 X and fructose. The serum was collected and analyzed for lipid profile total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein. Results: Methanolic extract of Nyctanthes arbor-tristis leaves at the doses of 200 and 400 mg/kg bd. wt showed significance (p < 0.01) decrease in lipid profile like TC, TG, LDL, VLDL and showed significance (p < 0.01) increase in HDL. Conclusion: Mena showed significant antihyperlipidemic activity with specific and non-specific mechanism which may be due to the presence of phytochemical constituents like phenols, triterpenoids and flavonoids.