INTERSTITIAL DELETION OF 9Q REVISITED

被引：8
|
作者：
KWONG, YL
HA, SY
CHING, LM
CHAN, LC
机构：
[1] University Department of Medicine, Queen Mary Hospital, Pokfulam Road
[2] University Department of Pathology, Queen Mary Hospital, Pokfulam Road
来源：
LEUKEMIA & LYMPHOMA | 1993年 / 12卷 / 1-2期
关键词：
INTERSTITIAL; 9Q-; ACUTE MYELOID LEUKEMIA;
D O I：
10.3109/10428199309059585
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interstitial deletion of the long arm of chromosome 9 (9q-) is an uncommon karyotypic abnormality in acute myeloid leukemia (AML). We report a case of acute myeloid leukemia, M6 according to the FAB criteria, in which 9q- was the sole karyotypic abnormality. From our own experience and that in the literature, interstitial 9q- seems to be associated with two specific morphologic/cytogenetic categories: AML M2 and t(8;21)(q22;q22)/trisomy 21; and as the sole karyotypic aberration in AML M1/M2(M6) with dyserythropoiesis. Examination of the published karyotypes shows that 9q13 to 9q21 is the commonest deleted segment, suggesting that this region may carry genes important in leukemogenesis.
引用
收藏
页码：153 / 155
页数：3
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