NADP-LINKED ISOZYMES ARE THE MAJOR FORMS OF ISOCITRATE DEHYDROGENASE IN MOUSE TYPE-1-LIKE ASTROCYTES

被引：8
|
作者：
JUURLINK, BHJ
机构：
[1] Department of Anatomy University of Saskatchewan, Saskatoon
来源：
LIFE SCIENCES | 1993年 / 52卷 / 13期
关键词：
D O I：
10.1016/0024-3205(93)90429-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The activities of cytosolic NADP-linked and mitochondrial NADP- and NAD-linked isocitrate dehydrogenases were examined in three-week-old mouse astroglial cultures. The respective activities were found to be 57 +/- 7, 101 +/- 3 and 8 +/- 1 nmoles NAD(P)+ reduced per mg protein per min. Both dibutyryl cyclic AMP and cortisol caused a significant increase in the activity of the mitochondrial as well as cytosolic NADP-linked isozymes.
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页码：1087 / 1090
页数：4
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