MURINE HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES REACTING WITH MLS(A) ANTIGENS

被引：0
|
作者：
DEGIORGI, L [1 ]
DEMATOS, C [1 ]
ELLIS, BA [1 ]
MATOSSIANROGERS, A [1 ]
机构：
[1] ROYAL LONDON HOSP,COLL MED,DEPT IMMUNOL,LONDON,ENGLAND
来源：
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS | 1993年 / 10卷 / 04期
关键词：
ANTI-SELF-ANTIBODY; MONOCLONAL ANTIIDIOTYPIC ANTIBODY; ANTI-MLS(A) ANTIBODY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Murine monoclonal antibodies have been developed from spleens of AKR mice hyperimmunised with the monoclonal antibody against TCR-Vbeta6. Two new monoclonal antibodies called AL-12-3 and AL-32-7 were able to specifically block Mls(a)-induced but not MHC-induced mixed lymphocyte responses in a dose-dependent manner. Both antibodies are mouse IgG3 lambda chain isotype and bind to Mls(a)-bearing lymphocytes from different strains of mice. The availability of such antibodies may well facilitate future research aimed at immunochemical and molecular characterization of Mls de terminants.
引用
收藏
页码：219 / 223
页数：5
相关论文
共 50 条
  • [1] MURINE HYBRIDOMAS SECRETING NATURAL MONOCLONAL-ANTIBODIES REACTING WITH SELF ANTIGENS
    DIGHIERO, G
    LYMBERI, P
    MAZIE, JC
    ROUYRE, S
    BUTLERBROWNE, GS
    WHALEN, RG
    AVRAMEAS, S
    [J]. JOURNAL OF IMMUNOLOGY, 1983, 131 (05): : 2267 - 2272
  • [2] PRODUCTION OF HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES TO THE GENUS FUSARIUM
    IANNELLI, D
    CAPPARELLI, R
    MARZIANO, F
    SCALA, F
    NOVIELLO, C
    [J]. MYCOTAXON, 1983, 17 (APR-) : 523 - 532
  • [3] DETECTION OF RETROVIRAL PARTICLES IN HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES
    BARTAL, AH
    FEIT, C
    ERLANDSON, RA
    HIRSHAUT, Y
    [J]. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1986, 174 (06) : 325 - 332
  • [4] HYBRIDOMAS SECRETING MONOCLONAL ANTIBODIES AGAINST TUMOR ASSOCIATED ANTIGENS OF A MURINE FIBRO-SARCOMA
    SIMRELL, CR
    MAINO, VC
    KLEIN, PA
    [J]. FEDERATION PROCEEDINGS, 1979, 38 (03) : 1422 - 1422
  • [5] ESTABLISHMENT OF HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES TO CHLAMYDIA-PSITTACI
    FUENTES, V
    LEFEBVRE, JF
    LEMA, F
    BISSAC, E
    ORFILA, J
    [J]. IMMUNOLOGY LETTERS, 1985, 10 (06) : 325 - 327
  • [6] HYBRIDOMAS AND MONOCLONAL-ANTIBODIES
    FUKS, BV
    SIDOROVICH, IG
    IGNATEVA, GA
    [J]. ZHURNAL VSESOYUZNOGO KHIMICHESKOGO OBSHCHESTVA IMENI D I MENDELEEVA, 1982, 27 (04): : 49 - 56
  • [7] MONOCLONAL-ANTIBODIES AND HYBRIDOMAS
    LEBACQ, P
    [J]. REVUE DE MEDECINE, 1981, 22 (38): : 2401 - 2407
  • [8] HYBRIDOMAS AND MONOCLONAL-ANTIBODIES
    BAZIN, H
    [J]. BIOFUTUR, 1986, (44) : 15 - 17
  • [9] MONOCLONAL-ANTIBODIES OF HYBRIDOMAS
    SINKOVICS, JG
    DREESMAN, GR
    [J]. REVIEWS OF INFECTIOUS DISEASES, 1983, 5 (01): : 9 - +
  • [10] HYBRIDOMAS AND MONOCLONAL-ANTIBODIES
    SCATTINI, CM
    [J]. PRENSA MEDICA ARGENTINA, 1981, 68 (14): : 579 - 582
12345