IMMUNOLOGICAL ANALYSIS OF ACQUIRED FACTOR-VIII INHIBITOR IN A CASE WITH IMMUNOLOGICAL DISORDER

被引：0
|
作者：
OKAMURA, T
YAMAUCHI, Y
FUKUDA, T
SUEHIRO, K
MURAKAWA, M
SHIBUYA, T
NAGASAWA, K
HARADA, M
NIHO, Y
机构：
来源：
ACTA HAEMATOLOGICA | 1991年 / 85卷 / 03期
关键词：
AUTOANTIBODY; FACTOR-VIII INHIBITOR; IGG SUBCLASS; POLYARTERITIS-NODOSA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer of inhibitor to factor VIII:C. As a result of immunological analysis, the inhibitor was found to be IgG type autoantibody having both kappa and lambda-light chains. The subclasses were IgG1 and IgG4. The inhibitor recognized the COOH-terminal light chain (72-kDa thrombin fragment) on the factor VIII molecule as an epitope.
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页码：153 / 155
页数：3
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