Subchronic Effect Of Carbendazim On Spermatogenesis And Fertility In Male Albino Rats Before And After Accelerated Storage

Subchronic effect of carbendazim on male albino rats reproductive system was investigated. Carbendazim (CBZ) was orally administered daily to rats for 65 successive days at four exposed doses (1/30 and 1/10 LD50 before and after accelerated storage) and control group. Fertility index, testes weight, sperm counts, levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone and histopathology of testes were examined to evaluate the reproductive efficiency of treated rats. Relative to control, the ingestion of carbendazim significantly reduced the fertility index, testis weight, the sperm counts and motility. Also, levels of LH and FSH were decreased. Histopathological examination showed testicular damages and severe changes in seminiferous tubules. The results indicated that carbendazim before and after accelerated storage produced reproductive toxic effect, resulting reduced fertility in male rats, but carbendazim before accelerated storage has obvious effect on fertility in rats than post storage.