Subchronic Effect Of Carbendazim On Spermatogenesis And Fertility In Male Albino Rats Before And After Accelerated Storage

被引：0

作者：

Abdel-Mobdy, Yasmin E. ^{[1
]}

Saleh, Mohammed A. ^{[2
]}

Nassar, Dyaa M. ^{[2
]}

Kandil, Mohamed A. ^{[1
]}

机构：

[1] Cairo Univ, Fac Agr, Entomol & Pesticide Dept, P Box 12613, Giza, Egypt

[2] Agr Res Ctr, Cent Agr Pesticides Lab, Pesticide Anal Res Dept, Nadi Said St, Giza, Egypt

来源：

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2018年 / 9卷 / 05期

关键词：

carbendazim; testosterone; luteinizing hormone; follicle stimulating hormone; sperm;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subchronic effect of carbendazim on male albino rats reproductive system was investigated. Carbendazim (CBZ) was orally administered daily to rats for 65 successive days at four exposed doses (1/30 and 1/10 LD50 before and after accelerated storage) and control group. Fertility index, testes weight, sperm counts, levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone and histopathology of testes were examined to evaluate the reproductive efficiency of treated rats. Relative to control, the ingestion of carbendazim significantly reduced the fertility index, testis weight, the sperm counts and motility. Also, levels of LH and FSH were decreased. Histopathological examination showed testicular damages and severe changes in seminiferous tubules. The results indicated that carbendazim before and after accelerated storage produced reproductive toxic effect, resulting reduced fertility in male rats, but carbendazim before accelerated storage has obvious effect on fertility in rats than post storage.

引用

页码：303 / 310

页数：8

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