Antibacterial, antifungal and cytotoxic activities of some medicinal plants against multidrug resistance pathogens

Medicinal plants are traditionally used for the treatment of human infections. The aim of the current study was to evaluate antibacterial, antifungal and cytotoxic activities; the crude of hexane, methanol and chloroform extracts from the leaves of Catharanthus roseus, Bixa orellana, Azadirachta indica and Dracaena sanderiana was assayed against two fungi and four bacteria using broth microdilution method and MTT assay. The methanol leaf extracts of B. orellana showed a significant activity against Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus and Candida albicans with minimum inhibitory concentrations 5.36, 7.12, 2.63 and 2.57 mg/ml, respectively. The half maximal inhibitory concentration extracts of C. roseus, B. orellana, A. indica and D. sanderiana against Huansen's skin fibroblast cell line were 50, 22, 19 and 37 mg/ml, respectively. The methanol extract of the four medicinal plants with minimum inhibitory concentration values from 2.57 to 47.85 mg/ml showed a significant antibacterial and antifungal activity against bacteria and fungi. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.