GADOLINIUM(III) INVIVO SPECIATION .2. A POTENTIOMETRIC STUDY OF GADOLINIUM(III) AMINO-ACID COMPLEXES

被引：0

作者：

JACKSON, GE

DUTOIT, JG

机构：

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 1992年 / 45卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gadolinium(III) complexes of valine, alanine, glycine, threonine, and glutamine have been studied potentiometrically at 25-degrees-C and an ionic strength of 0,15 mol dm-3 NaCl. These results have been used in a computer model to calculate the gadolinium(III) species distribution in blood plasma. The results indicate that these amino acid complexes are not important in vivo, but that at low concentration (< 2 x 10(-4) mol dm-3) the metal ion is bound almost exclusively as [Gd(citrate)(OH)]- (69,1%) and [Gd(citrate)(OH)2]2- (24,4%). At higher concentrations the metal ion is distributed over several complexes with [Gd(lactate)]2+ (9,0%) becoming important. The inclusion of transferrin bound by Gd(III) in the simulation (uptake of Gd(III) by transferrin is slow) shows that at 2 x 10(-4 )mol dm-3 Gd(III) at most 36,9% of the Gd(III) will be bound to transferrin [Gd2(transferrin)].

引用

页码：82 / 85

页数：4

共 50 条

[21] Luminescent Properties of Europium(III), Gadolinium(III), and Terbium(III) Complexes with Alkyloxybenzoic Acids
Kolokolov, F. A.
Magomadova, M. A.
Shapieva, Kh K.
Panyushkin, V. T.
[J]. JOURNAL OF APPLIED SPECTROSCOPY, 2019, 86 (02) : 321 - 324
[22] THERMAL AND PHOTOREACTIONS OF CR(III) AMINO-ACID COMPLEXES
CASTILLO, C
BACA, A
COLEMAN, WF
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1977, 173 (MAR20): : 111 - 111
[23] AMINO-ACID COMPLEXES OF [CO(III)(TRIEN)](+3)
EDUOK, EE
KASHYAP, RP
NAGL, A
BOURNE, SA
WATSON, WH
[J]. JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 1994, 24 (09) : 627 - 638
[24] COMPLEXING OF GADOLINIUM(III) WITH MALIC-ACID
USTYAK, VV
SALNIKOV, YI
[J]. ZHURNAL NEORGANICHESKOI KHIMII, 1984, 29 (03): : 679 - 683
[25] ELECTRONIC-SPECTRA OF COMPLEXES OF NEODYMIUM (III) AND PRASEODYMIUM (III) WITH AMINO-ACID
BHUTRA, MP
GUPTA, AK
[J]. INDIAN JOURNAL OF PURE & APPLIED PHYSICS, 1983, 21 (06) : 374 - 375
[26] Coordination compounds of europium(III), terbium(III), dysprosium(III), samarium(III), and gadolinium(III) with 2-acetylbenzoic acid
Pikula, A. A.
Kolechko, D. V.
Panyushkin, V. T.
Oflidi, A. I.
Nazarenko, M. A.
[J]. RUSSIAN JOURNAL OF INORGANIC CHEMISTRY, 2013, 58 (07) : 773 - 776
[27] SOLUBILITY DIAGRAMS OF COBALT(III) COMPLEXES CONTAINING AMINO-ACID .2. SPONTANEOUS RESOLUTION OF BIS(ETHYLENEDIAMINE)GLYCINATOCOBALT(III) SALTS
KAKI, S
YAMANARI, K
SHIMURA, Y
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1982, 55 (03) : 769 - 774
[28] GADOLINIUM Gd(III) COMPLEXES WITH DERIVATIVES OF NITRILOACETIC ACID: SYNTHESIS AND BIOLOGICAL PROPERTIES
Karwowski, Boleslaw
Witczak, Michal
Mikiciuk-Olasik, Elzbieta
Studniarek, Malgorzata
[J]. ACTA POLONIAE PHARMACEUTICA, 2008, 65 (05): : 535 - 541
[29] MIXED COMPLEXES OF NEODYMIUM(III), SAMARIUM(III), GADOLINIUM(III) AND HOLMIUM(III) IN AQUEOUS-MEDIUM
MARATHE, DG
MUNSHI, KN
[J]. INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1982, 21 (02): : 205 - 206
[30] Extracellular biodegradable macromolecular gadolinium(III) complexes for MRI
Lu, ZR
Parker, DL
Goodrich, KC
Wang, XH
Dalle, JG
Buswell, HR
[J]. MAGNETIC RESONANCE IN MEDICINE, 2004, 51 (01) : 27 - 34

← 1 2 3 4 5 →