ANTIMUSCARINIC ACTIVITY OF TELENZEPINE ON ISOLATED HUMAN URINARY-BLADDER - NO ROLE FOR M1-MUSCARINIC RECEPTORS

被引：12

作者：

POLI, E ^{[1
]}

MONICA, B ^{[1
]}

ZAPPIA, L ^{[1
]}

POZZOLI, C ^{[1
]}

BERTACCINI, G ^{[1
]}

机构：

[1] UNIV PARMA, SCH MED, DEPT UROL, I-43100 PARMA, ITALY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 04期

关键词：

D O I：

10.1016/0306-3623(92)90144-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The antimuscarinic activity of the selective M1-blocking drug, telenzepine, was investigated on the isolated human urinary bladder, contracted with exogenous muscarinic agonists and with field stimulation 2. Telenzepine (3 x 10(-8)-10(-5)M) concentration-dependently shifted to the right the dose-response curves of bethanechol, acetylcholine and McN-A343, and partially depressed the electrically-evoked twitch responses. 3. pA2 values of telenzepine against bethanechol and McN-A343 were very close. 4. McN-A343 did not modify twitch responses elicited by field stimulation up to 10(-5)M. 5. The lack of muscarinic M1 receptors in human detrusor muscle is confirmed

引用

页码：659 / 664

页数：6

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