Cdc6 A multi-functional molecular switch with critical role in carcinogenesis

被引：31
|
作者：
Petrakis, Thodoris G. [1 ]
Vougas, Konstantinos [2 ]
Gorgoulis, Vassilis G. [1 ,3 ]
机构：
[1] Univ Athens, Mol Carcinogenesis Grp, Dept Histol & Embryol, Sch Med, Athens, Greece
[2] Acad Athens, Biomed Res Fdn, Ctr Basic Res 2, Proteom Res Unit, Athens, Greece
[3] Acad Athens, Biomed Res Fdn, Athens, Greece
来源：
TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 03期
关键词：
origin of replication; chromatin remodeling; human cancer; histones; heterochromatinization; chromosomal instability; insulator;
D O I：
10.4161/trns.20301
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Research in the last decade revealed n additional role for the Replication Licensing Factor Cdc6 in transcriptional regulation. This novel function has been linked to human cancer development. Here, we-summarize all the findings arguing over a role of Cdc6 as a transcriptional repressor and shed light toward new research directions for this field.
引用
收藏
页码：124 / 129
页数：6
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