AN ASYMMETRIC-SYNTHESIS OF (-)-DEOXYPODOPHYLLOTOXIN

被引：44

作者：

BOGUCKI, DE ^{[1
]}

CHARLTON, JL ^{[1
]}

机构：

[1] UNIV MANITOBA,DEPT CHEM,WINNIPEG,MB R3T 2N2,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 03期

关键词：

D O I：

10.1021/jo00108a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diels-Alder cycloaddition between the fumarate of methyl (S)-mandelate (22) and alpha-hydroxy-alpha-aryl-o-quinodimethane 21 produces an endo cycloadduct (23) in 58% yield. The preparation of the precursor to o-quinodimethane 21 and the conversion of cycloadduct 23 to optically pure (-)-deoxypodophyllotoxin (1) is described.

引用

页码：588 / 593

页数：6

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