LIQUID-CHROMATOGRAPHIC METHODS FOR DETERMINATION OF TRAZODONE AND RELATED-COMPOUNDS IN DRUG RAW-MATERIALS

Liquid chromatographic methods for the determination of trazodone and 10 related compounds are described. An octylsilane column was used with a mobile phase of tetrahydrofuran-methanol- acetonitrile-0.5% trifluoroacetic acid (6 + 2 + 6 + 27) and detection at 248 nm. Minimum quantifiable amounts of the related compounds were less than 0.05% based on coefficients of variation of less than 10%. Total impurities in 5 raw drug materials were less than 1%.