RISK-FACTORS FOR ALZHEIMERS-DISEASE AND DEMENTIA - A CASE-CONTROL STUDY BASED ON THE MRC ELDERLY HYPERTENSION TRIAL

被引:0
|
作者
PRINCE, M [1 ]
CULLEN, M [1 ]
MANN, A [1 ]
机构
[1] ROYAL FREE HOSP,SCH MED,ACAD DEPT PSYCHIAT,LONDON,ENGLAND
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We surveyed 1,545 subjects-recruited into the UK Medical Research Council elderly hypertension treatment trial between 1982 and 1987-to detect incident cases of dementia, identifying 50 cases of dementia, including 31 cases of probable or possible Alzheimer's disease (AD). These we compared with 223 unimpaired, unmatched controls from the same population for exposure to familial, cardiovascular, educational, and geographic risk factors for dementia. Our study confirms the association of family history of dementia with dementia (odds ratio [OR] = 4.36) and AD (OR = 4.69), and of advanced age with dementia (OR = 2.81). Rural residence exerted a protective effect for dementia (OR = 0.21) and AD (OR = 0.28). We report near-significant associations between AD and dementia and several cardiovascular risk factors (ECG ischemia, systolic hypertension, and smoking) among subjects lacking a family history of dementia. We postulate the existence of a nonfamilial form of dementia transcending traditional categories of multiinfarct dementia and AD, more common among urban residents, and mediated through Vascular pathology. Risk factors reported elsewhere but not confirmed in this study were advanced maternal age and winter season of birth.
引用
收藏
页码:97 / 104
页数:8
相关论文
共 50 条
  • [31] RISK-FACTORS AND GENETIC BACKGROUND FOR ALZHEIMERS-DISEASE
    AMADUCCI, L
    LIPPI, A
    ACTA NEUROLOGICA SCANDINAVICA, 1988, 77 : 13 - 18
  • [32] DESCRIPTIVE EPIDEMIOLOGY AND RISK-FACTORS FOR ALZHEIMERS-DISEASE
    AMADUCCI, L
    FALCINI, M
    LIPPI, A
    ACTA NEUROLOGICA SCANDINAVICA, 1992, 85 : 21 - 25
  • [33] THE EPIDEMIOLOGY OF ALZHEIMERS-DISEASE - BEYOND RISK-FACTORS
    MORTIMER, JA
    NEUROBIOLOGY OF AGING, 1994, 15 : S39 - S39
  • [34] FREQUENCY, DISTRIBUTION, AND RISK-FACTORS FOR ALZHEIMERS-DISEASE
    ROCCA, WA
    NURSING CLINICS OF NORTH AMERICA, 1994, 29 (01) : 101 - 111
  • [35] THE RISK-FACTORS FOR ALZHEIMERS-DISEASE - A REVIEW AND A HYPOTHESIS
    HENDERSON, AS
    ACTA PSYCHIATRICA SCANDINAVICA, 1988, 78 (03) : 257 - 275
  • [36] RISK-FACTORS FOR CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE
    BAKER, FM
    JORDAN, B
    BARCLAY, L
    SCHOENBERG, BS
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1993, 8 (05) : 379 - 385
  • [37] RISK-FACTORS FOR SYNCOPE IN THE ELDERLY - A PROSPECTIVE CASE-CONTROL STUDY
    LIPSITZ, LA
    GALVAGNO, FC
    WEI, JY
    ROWE, JW
    GERONTOLOGIST, 1985, 25 : 60 - 60
  • [38] A CASE-CONTROL STUDY OF MATERNAL AGE IN ALZHEIMERS-DISEASE
    ENGLISH, D
    COHEN, D
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1985, 33 (03) : 167 - 169
  • [39] EDUCATION AND OCCUPATION AS RISK-FACTORS FOR DEMENTIA - A POPULATION-BASED CASE-CONTROL STUDY
    BONAIUTO, S
    ROCCA, WA
    LIPPI, A
    GIANNANDREA, E
    MELE, M
    CAVARZERAN, F
    AMADUCCI, L
    NEUROEPIDEMIOLOGY, 1995, 14 (03) : 101 - 109
  • [40] THE CANADIAN STUDY OF HEALTH AND AGING - RISK-FACTORS FOR ALZHEIMERS-DISEASE IN CANADA
    MCDOWELL, I
    HILL, G
    LINDSAY, J
    HELLIWELL, B
    COSTA, L
    BEATTIE, L
    HERTZMAN, C
    TUOKKO, H
    GUTMAN, G
    PARHAD, I
    PARBOOSINGH, J
    BLAND, R
    NEWMAN, S
    DOBBS, A
    HAZLETT, C
    RULE, B
    DARCY, C
    SEGALL, A
    CHAPPELL, N
    MANFREDA, J
    MONTGOMERY, P
    OSTBYE, T
    ROBERTSON, J
    HACHINSKI, V
    CHAMBERS, L
    MUNROEBLUM, H
    EASTWOOD, R
    RIFAT, S
    VERDON, J
    NAVARRO, J
    GAUTHIER, S
    WOLFSON, C
    BAUMGARTEN, M
    SKA, B
    JOANETTE, Y
    KERGOAT, MJ
    NAZERALI, N
    HEBERT, R
    BRAVO, G
    DOYON, J
    BOUCHARD, R
    MORIN, J
    GAUVREAU, D
    BALRAM, C
    ROCKWOOD, K
    GRAY, J
    FISK, J
    NILSSON, T
    DONALD, A
    BUEHLER, S
    NEUROLOGY, 1994, 44 (11) : 2073 - 2080