HYDRODYNAMIC BEHAVIOR OF HUMAN AND BACTERIAL THYMIDYLATE SYNTHETASES AND THYMIDYLATE SYNTHETASE-5-FLUORO-2'-DEOXYURIDYLATE-5,10-METHYLENETETRAHYDROFOLATE COMPLEXES - EVIDENCE FOR LARGE CONFORMATIONAL-CHANGES DURING CATALYSIS

被引：31

作者：

LOCKSHIN, A

DANENBERG, PV

机构：

[1] UNIV SO CALIF,SCH MED,DEPT BIOL,LOS ANGELES,CA 90033

[2] UNIV SO CALIF,CTR COMPREHENS CANC,SCH MED,LOS ANGELES,CA 90033

来源：

BIOCHEMISTRY | 1980年 / 19卷 / 18期

关键词：

D O I：

10.1021/bi00559a016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：4244 / 4251

页数：8

共 7 条

[1] EFFECT OF RANEY-NICKEL ON COVALENT THYMIDYLATE SYNTHETASE-5-FLUORO-2'-DEOXYURIDYLATE-5,10-METHYLENETETRAHYDROFOLATE COMPLEX
DANENBERG, PV
HEIDELBERGER, C
BIOCHEMISTRY, 1976, 15 (06) : 1331 - 1337
[2] EVIDENCE FROM CHEMICAL DEGRADATION STUDIES FOR A COVALENT BOND FROM 5-FLUORO-2'-DEOXYURIDYLATE TO N-5 OF TETRAHYDROFOLATE IN THE TERNARY COMPLEX OF THYMIDYLATE SYNTHETASE-5-FLUORO-2'-DEOXYURIDYLATE-5,10-METHYLENETETRAHYDROFOLATE
PELLINO, AM
DANENBERG, PV
JOURNAL OF BIOLOGICAL CHEMISTRY, 1985, 260 (20) : 996 - 1000
[3] EFFECT OF 5,10-METHYLENETETRAHYDROFOLATE ON DISSOCIATION OF 5-FLUORO-2'-DEOXYURIDYLATE FROM THYMIDYLATE SYNTHETASE - EVIDENCE FOR AN ORDERED MECHANISM
DANENBERG, PV
DANENBERG, KD
BIOCHEMISTRY, 1978, 17 (19) : 4018 - 4024
[4] THYMIDYLATE SYNTHETASE - STUDIES ON PEPTIDE CONTAINING COVALENTLY BOUND 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE
POGOLOTTI, AL
IVANETICH, KM
SOMMER, H
SANTI, DV
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 70 (03) : 972 - 978
[5] SECONDARY ALPHA-HYDROGEN ISOTOPE EFFECTS ON THE INTERACTION OF 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE WITH THYMIDYLATE SYNTHETASE
BRUICE, TW
SANTI, DV
BIOCHEMISTRY, 1982, 21 (26) : 6703 - 6709
[6] EFFECT OF POLYGLUTAMYLATION OF 5,10-METHYLENETETRAHYDROFOLATE ON THE BINDING OF 5-FLUORO-2'-DEOXYURIDYLATE TO THYMIDYLATE SYNTHASE PURIFIED FROM A HUMAN-COLON ADENOCARCINOMA XENOGRAFT
RADPARVAR, S
HOUGHTON, PJ
HOUGHTON, JA
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (02) : 335 - 342
[7] F-19 NUCLEAR MAGNETIC-RESONANCE INVESTIGATION OF TERNARY COMPLEX FORMED BETWEEN NATIVE THYMIDYLATE SYNTHETASE, 5-FLUORO-2'-DEOXYURIDYLATE, AND 5,10-METHYLENETETRAHYDROFOLATE
BYRD, RA
DAWSON, WH
ELLIS, PD
DUNLAP, RB
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (18) : 6139 - 6141

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