MODULATION OF RESTING MEMBRANE-POTENTIAL OF HUMAN AND RAT HEPATOCYTES BY SEX STEROIDS

被引：8
|
作者：
MOTZKIN, SM [1 ]
FEINSTEIN, J [1 ]
TIRIBELLI, C [1 ]
机构：
[1] UNIV TRIESTE,I-34100 TRIESTE,ITALY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期
关键词：
D O I：
10.1016/0006-291X(90)91570-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of sex steroids on the regulation of hepatocyte resting membrane potential (Em) was investigated. In adult rat liver snips, Em was significantly lower in males than females. In prepubertal animals no sex related difference was observed and the Em was comparable to that of adult females. Exposure of the human liver cell line, HepG2 cells, to 10μM testosterone resulted in a significant hyperpolarization. These data indicate that the more negative Em found in male animals is specifically due to the influence of testosterone. In addition, they also suggest that sex hormone regulation of Em is maintained by HepG2 cells. This cell line may prove to be a good model for the study of liver cell function. © 1990.
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页码：1163 / 1166
页数：4
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