Oral melanomas occur most often on the palate and gingiva with the maxillary arch affected 80% of the time. Melanosis may exist many years before a definitive biopsy. tong-standing lesions may ulcerate but lack rolled borders or induration, features commonly associated with squamous cell carcinoma. Melanoma that involves oral mucosa is rare with an extremely poor prognosis. Surgical management remains the preferred treatment in combination with chemotherapy. irradiation therapy is used occasionally as a primary modality in the elderly and medically compromised patients. Lymph node dissection is not routinely practiced. The poor prognosis oi oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied.
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Univ Western Ontario, Dept Med & Biochem, London, ON, CanadaUniv Western Ontario, Dept Med & Biochem, London, ON, Canada
Zamel, Rola
Khan, Razi
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Univ Western Ontario, Dept Med & Biochem, London, ON, CanadaUniv Western Ontario, Dept Med & Biochem, London, ON, Canada
Khan, Razi
Pollex, Rebecca L.
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Univ Western Ontario, Robarts Res Inst, Schulich Sch Med & Dent, London, ON, CanadaUniv Western Ontario, Dept Med & Biochem, London, ON, Canada
Pollex, Rebecca L.
Hegele, Robert A.
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Univ Western Ontario, Dept Med & Biochem, London, ON, Canada
Univ Western Ontario, Robarts Res Inst, Schulich Sch Med & Dent, London, ON, CanadaUniv Western Ontario, Dept Med & Biochem, London, ON, Canada