EXPRESSION OF C-MYC MESSENGER-RNA AND PROTEIN IN HUMAN ENDOMETRIAL CARCINOMA - SIMULTANEOUS STUDY OF IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY

被引：2
|
作者：
SATO, S
JIKO, K
ITO, K
OZAWA, N
YAJIMA, A
MIYAZAKI, S
SASANO, H
机构：
[1] TOHOKU UNIV, SCH MED, DEPT PATHOL 2, SENDAI, MIYAGI 980, JAPAN
[2] TOHOKU UNIV, SCH MED, DEPT SURG 2, SENDAI, MIYAGI 980, JAPAN
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 170卷 / 04期
关键词：
C-MYC MESSENGER RNA AND PROTEIN; ENDOMETRIAL CARCINOMA; IN-SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY;
D O I：
10.1620/tjem.170.229
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.
引用
收藏
页码：229 / 234
页数：6
相关论文
共 50 条
  • [21] C-MYC MESSENGER-RNA EXPRESSION IN NON-HODGKINS-LYMPHOMAS
    FELLBAUM, C
    RADASZKIEWICZ, T
    RUHRI, C
    PUTZ, B
    LEHMACHER, W
    HOFLER, H
    VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1992, 62 (01) : 61 - 68
  • [22] EXPRESSION OF C-MYC AND BCL-2 MESSENGER-RNA IN THYMOCYTES
    BROUSSARDDIEHL, C
    SCHEUERMANN, RH
    FASEB JOURNAL, 1994, 8 (05): : A784 - A784
  • [23] EXPRESSION OF CATHEPSIN-D MESSENGER-RNA IN OVARIAN NEOPLASIA - DEMONSTRATION BY NON ISOTOPIC IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY
    CARDILLO, MR
    WALKER, RM
    YAP, EPH
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 1995, 14 (02) : 155 - 162
  • [24] INSITU HYBRIDIZATION USING A FLUORESCENT AVIDINBIOTIN TECHNIQUE FOR DETECTION OF C-MYC MESSENGER-RNA
    TSUJI, Y
    HIRABAYASHI, K
    URATA, Y
    KUZUHARA, A
    TAKESHITA, H
    KUSUZAKI, K
    YAMANOUCHI, H
    YANO, J
    KAMACHI, M
    ASHIHARA, T
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 1986, 19 (03) : 414 - 414
  • [25] EXPRESSION OF VASCULAR CELL-ADHESION MOLECULE-1 MESSENGER-RNA AND PROTEIN IN RHEUMATOID SYNOVIUM DEMONSTRATED BY IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY
    KRIEGSMANN, J
    KEYSZER, GM
    GEILER, T
    BRAUER, R
    GAY, RE
    GAY, S
    LABORATORY INVESTIGATION, 1995, 72 (02) : 209 - 214
  • [26] TUMOR-NECROSIS-FACTOR-ALPHA MESSENGER-RNA AND PROTEIN IN ENDOMETRIAL TUMORS - ANALYSIS BY IN-SITU HYBRIDIZATION AND IMMUNOCYTOCHEMISTRY
    GARCIA, FU
    CHEN, HL
    YANG, Y
    PACE, JL
    HU, XL
    HUNT, JS
    HUMAN PATHOLOGY, 1994, 25 (12) : 1324 - 1331
  • [27] ANALYSIS BY IN-SITU HYBRIDIZATION OF CYTOKINE MESSENGER-RNA EXPRESSION IN THE MURINE DEVELOPING THYMUS
    DEMAN, J
    HUMBLET, C
    MARTIN, MT
    BONIVER, J
    DEFRESNE, MP
    INTERNATIONAL IMMUNOLOGY, 1994, 6 (10) : 1613 - 1619
  • [28] DECAY OF HUMAN C-MYC MESSENGER-RNA IN CELL-FREE-EXTRACTS
    BREWER, G
    PELTZ, S
    ROSS, J
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 137 - 137
  • [29] PURIFICATION AND PROPERTIES OF A PROTEIN THAT BINDS TO THE C-TERMINAL CODING REGION OF HUMAN C-MYC MESSENGER-RNA
    PROKIPCAK, RD
    HERRICK, DJ
    ROSS, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (12) : 9261 - 9269
  • [30] PROTHYMOSIN-ALPHA MESSENGER-RNA EXPRESSION CORRELATES WITH THAT OF C-MYC IN HUMAN COLON-CANCER
    MORI, M
    BARNARD, GF
    STANIUNAS, RJ
    JESSUP, JM
    STEELE, GD
    CHEN, LB
    ONCOGENE, 1993, 8 (10) : 2821 - 2826
12345