EXPRESSION OF C-MYC MESSENGER-RNA AND PROTEIN IN HUMAN ENDOMETRIAL CARCINOMA - SIMULTANEOUS STUDY OF IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY

被引：2
|
作者：
SATO, S
JIKO, K
ITO, K
OZAWA, N
YAJIMA, A
MIYAZAKI, S
SASANO, H
机构：
[1] TOHOKU UNIV, SCH MED, DEPT PATHOL 2, SENDAI, MIYAGI 980, JAPAN
[2] TOHOKU UNIV, SCH MED, DEPT SURG 2, SENDAI, MIYAGI 980, JAPAN
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 170卷 / 04期
关键词：
C-MYC MESSENGER RNA AND PROTEIN; ENDOMETRIAL CARCINOMA; IN-SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY;
D O I：
10.1620/tjem.170.229
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.
引用
收藏
页码：229 / 234
页数：6
相关论文
共 50 条
  • [1] EXPRESSION IN-SITU OF C-MYC MESSENGER-RNA AND C-MYC PROTEIN DURING SPERMATOGENESIS IN THE ADULT-MOUSE
    UETANI, N
    YAMAURA, K
    SATO, K
    CELL BIOLOGY INTERNATIONAL, 1994, 18 (02) : 85 - 87
  • [2] EXPRESSION OF ACETYLCHOLINESTERASE MESSENGER-RNA IN HUMAN BRAIN - AN IN-SITU HYBRIDIZATION STUDY
    LANDWEHRMEYER, B
    PROBST, A
    PALACIOS, JM
    MENGOD, G
    NEUROSCIENCE, 1993, 57 (03) : 615 - 634
  • [3] DETECTION OF C-MYC MESSENGER-RNA BY INSITU HYBRIDIZATION
    HOSOKAWA, Y
    UEDA, K
    NISHI, M
    TSUJI, Y
    MURATA, S
    URATA, Y
    TSUCHIHASHI, Y
    ASHIHARA, T
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 1987, 20 (06) : 707 - 707
  • [4] COLOCALIZATION OF MESSENGER-RNA AND PROTEIN USING IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY IN TESTICULAR TISSUE
    MILLAR, MR
    SHARPE, RM
    MAGUIRE, SM
    GAUGHAN, J
    SAUNDERS, PTK
    MICROSCOPY RESEARCH AND TECHNIQUE, 1995, 32 (06) : 498 - 503
  • [5] ANALYSIS OF ODC AND C-MYC GENE-EXPRESSION IN HEPATOCELLULAR-CARCINOMA BY IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY
    GAN, FY
    GESELL, MS
    ALOUSI, M
    LUK, GD
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (08) : 1185 - 1196
  • [6] INTRACELLULAR DYNAMICS OF C-MYC MESSENGER-RNA TRAFFIC IN SINGLE CELLS IN-SITU
    PALLAVICINI, MG
    GEORGE, T
    DETERESA, PS
    AMENDOLA, R
    GRAY, JW
    JOURNAL OF CELLULAR PHYSIOLOGY, 1994, 158 (02) : 223 - 230
  • [7] EXPRESSION OF RECOVERIN MESSENGER-RNA IN THE HUMAN RETINA - LOCALIZATION BY IN-SITU HYBRIDIZATION
    WIECHMANN, AF
    HAMMARBACK, JA
    EXPERIMENTAL EYE RESEARCH, 1993, 57 (06) : 763 - 769
  • [8] C-MYC MESSENGER-RNA EXPRESSION DURING DIFFERENTIATION OF HL-60 CELLS AS ANALYZED BY IN SITU HYBRIDIZATION
    UEDA, K
    HOSOKAWA, Y
    TSUJI, Y
    URATA, Y
    TSUCHIHASHI, Y
    ASHIHARA, T
    CELL STRUCTURE AND FUNCTION, 1987, 12 (06) : 710 - 710
  • [9] DISCUSSION ON THE METABOLISM OF C-MYC MESSENGER-RNA AND PROTEIN
    RABBITTS, TH
    VANSTRAATEN, P
    RABBITTS, PH
    WATSON, J
    PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1985, 226 (1242): : 79 - 82
  • [10] Detection of c-myc gene expression in nasopharyngeal carcinoma by nonradioactive in situ hybridization and immunohistochemistry
    罗均利
    肖健云
    陶正德
    李晓燕
    中华医学杂志(英文版), 1997, (03) : 69 - 72
12345